MTSAXONREGENERATION

Microtubule dynamics and neuronal cargo trafficking during dendrite to axon switching

Coordinatore	UNIVERSITEIT UTRECHT    more  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Astrid Cognome: Haijma Email: send email Telefono: +3130 253 9227
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	183˙805 €
EC contributo	183˙805 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-11   -   2015-03-10

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Astrid Cognome: Haijma Email: send email Telefono: +3130 253 9227	NL (UTRECHT)	coordinator	183˙805.80

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 Obiettivo del progetto (Objective)

'Neurons are highly polarized cells, possessing two distinct types of processes, dendrites and a single axon. In cultured mammalian neurons, axons have uniform polarity microtubules (MTs) with plus ends distal to the cell body, while dendrites have mixed polarity with about half plus-end-out and half minus-end-out MTs. Several studies suggest that neurons have a tremendous capacity for axon regeneration, even in response to total axon removal they can convert a dendrite to a regenerating axon. This process of regenerating does seem to be accompanied by changing the MT cytoskeleton from the dendritic polarity to the axonal one. Various signaling molecules are implicated in the early events of neuronal polarization, but little is known about regulation of MT polarity orientation during these initial stages and in processes involves in rebuilding the entire neuronal MT cytoskeleton. The purpose of this project is trying to understand the mechanism underlying the rearranged of MT dynamics and polarity after axon removal in hippocampal neurons. First, we will describe this re-polarization and MT dynamics during axonal regeneration, and then we will deepen in how microtubule-associated proteins TIPs, motor proteins, like dynein, and Rho-GTPase proteins could regulate this process.'