TOBI

Targeting OBesity-driven Inflammation

 Coordinatore MEDIZINISCHE UNIVERSITAET WIEN 

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Josef
Cognome: Smolen
Email: send email
Telefono: +43 1 40400 4300
Fax: +43 1 40400 4306

 Nazionalità Coordinatore Austria [AT]
 Sito del progetto http://www.tobi-project.eu/
 Totale costo 3˙862˙481 €
 EC contributo 2˙980˙964 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-01-01   -   2011-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Josef
Cognome: Smolen
Email: send email
Telefono: +43 1 40400 4300
Fax: +43 1 40400 4306

AT (WIEN) coordinator 0.00
2    BIOLUTION GMBH

 Organization address address: Karl-Farkas-Gasse 22
city: WIEN
postcode: 1030

contact info
Titolo: Dr.
Nome: Iris
Cognome: Grünert
Email: send email
Telefono: -7869568
Fax: -7869573

AT (WIEN) participant 0.00
3    GENFIT SA

 Organization address address: Avenue Eugene Avinee 885
city: LOOS
postcode: 59120

contact info
Titolo: Mr.
Nome: Matthieu
Cognome: Dubruque
Email: send email
Telefono: -6068
Fax: -5987

FR (LOOS) participant 0.00
4    INSTITUT PASTEUR DE LILLE FONDATION

 Organization address address: 1 Rue du professeur Calmette
city: LILLE
postcode: 59019

contact info
Titolo: Ms.
Nome: Fabienne
Cognome: Jean
Email: send email
Telefono: -9284
Fax: -9930

FR (LILLE) participant 0.00
5    PHARM-ANALYT LABOR GMBH

 Organization address address: Ferdinand Pichlergasse 2
city: BADEN BEI WIEN
postcode: 2500

contact info
Titolo: Dr.
Nome: Daniel
Cognome: Mascher
Email: send email
Telefono: -4907239
Fax: -492718

AT (BADEN BEI WIEN) participant 0.00
6    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: -9761
Fax: -9760

UK (EDINBURGH) participant 0.00
7    UNIVERSITA POLITECNICA DELLE MARCHE

 Organization address address: PIAZZA ROMA 22
city: ANCONA
postcode: 60121

contact info
Titolo: Dr.
Nome: Saverio
Cognome: Cinti
Email: send email
Telefono: +39 071 220 6088
Fax: 390712000000

IT (ANCONA) participant 0.00
8    UNIVERSITAET GRAZ

 Organization address address: UNIVERSITAETSPLATZ 3
city: GRAZ
postcode: 8010

contact info
Titolo: Prof.
Nome: Rudolf
Cognome: Zechner
Email: send email
Telefono: -2553
Fax: -9669

AT (GRAZ) participant 0.00
9    UNIVERSITAET ZU KOELN

 Organization address address: ALBERTUS MAGNUS PLATZ
city: KOELN
postcode: 50923

contact info
Nome: Jutta
Cognome: Lanedvogt
Email: send email
Telefono: +49 221 478 -05204
Fax: +49 221 47887752

DE (KOELN) participant 0.00
10    UNIVERSITY OF DURHAM

 Organization address address: STOCKTON ROAD THE PALATINE CENTRE
city: DURHAM
postcode: DH1 3LE

contact info
Titolo: Ms.
Nome: Wendy
Cognome: Harle
Email: send email
Telefono: -5120
Fax: -5115

UK (DURHAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

adipocyte    vascular    insulin    tissues    strategies    obesity    function    adipokines    pathways    lipid    tissue    mechanisms    dysfunction    drift    molecular    drug    alterations    studied    adipokine    inflammatory    tobi    signalling    interfere    adipose    mediated   

 Obiettivo del progetto (Objective)

'The TOBI project aims to analyse mechanisms provoking adipokine-mediated crosstalk and an inflammatory drift in obese patients. It will be the remit of this project to develop novel strategies to reduce or reverse major adipokine-mediated adverse interactions in peripheral tissues and by periorganic adipose tissue, namely insulin resistance and vascular dysfunction, respectively. Special attention will be given to the study of novel lipid-derived adipokines and the identification of targets for drug development that could interfere with the obesity-associated inflammatory drift. TOBI research focuses on molecular mechanisms initiating and promoting inflammatory signalling pathways in adipocytes and adipose tissue macrophages that cause a shift to inflammatory adipokines to interfere with insulin sensitivity and vascular function. Adipocyte dysfunction by alterations in ER stress signalling and lipolysis will be analysed as probable starting points of adipocyte inflammatory alterations. Signalling pathways and transcription factors controlling expression of inflammatory adipokines and anti-inflammatory adipokines will be studied. TOBI will particularly investigate lipid-derived adipokines that have been little studied to date. Key molecules of pathophysiological relevance will be validated for their potential as targets for drug development. The TOBI consortium will mount a comprehensive collaborative program for analysing the molecular mechanisms underlying regulation of adipokine production and their function in target tissues using genetic, molecular and biochemical approaches. The consortium combines all necessary expertise to investigate the basis of the obesity-associated inflammatory drift. A TOBI toolbox will be developed that strengthen collaboration and comparability of results. In addition the consortium includes relevant partners to exploit the results by translating them into new treatment strategies for obesity-associated adipokine-mediated disorders.'

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