GHCA

Genetics of High Cognitive Abilities

 Coordinatore KING'S COLLEGE LONDON 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 2˙462˙298 €
 EC contributo 2˙462˙298 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-ADG_20110406
 Funding Scheme ERC-AG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2017-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Dr.
Nome: Paul
Cognome: Labbett
Email: send email
Telefono: +44 20 7848 8184
Fax: 442078000000

UK (LONDON) hostInstitution 2˙462˙298.20
2    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Prof.
Nome: Robert
Cognome: Plomin
Email: send email
Telefono: +44 20 7848 0895

UK (LONDON) hostInstitution 2˙462˙298.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cognitive    substantially    genes    heritability    first    individuals    variants    few    ability    pi    genome    ghca    responsible    dna    life    abilities    microarrays    sequence    gwa   

 Obiettivo del progetto (Objective)

'Although there are many types of cognitive ability, they correlate substantially; general cognitive ability (g) indexes this covariance and is an important predictor of many key life outcomes. The PI’s 40-year programme of research has contributed to a once controversial finding that is now widely accepted: Individual differences in g are substantially influenced by genes, as well as the environment. The proposed research will use cutting-edge methodologies to identify genes responsible for the heritability of g.

The PI’s research group conducted the first genome-wide association (GWA) studies of g and of specific cognitive abilities using microarrays to genotype common single-nucleotide polymorphisms (SNPs) sampled across the genome. Although GWA studies by the PI and others are beginning to identify a few of the genes responsible for genetic influence on cognitive abilities and disabilities, there remains a problem of ‘missing heritability’, in the search for which the proposed research features two innovations.

First, by studying a large sample of individuals with exceptionally high g, statistical power to detect associations of small effect size will be boosted. The project will capitalise on the unique Genetics of High Cognitive Abilities (GHCA) resource recently created by the PI: a sample of 2000 individuals with IQs greater than 160, which represents the 99.997th percentile and exceeds the average IQ of Nobel Prize winners.

Second, the project will go beyond reliance on common-SNP microarrays to exploit DNA sequencing, which captures all DNA sequence variation including rare variants. The project will fully sequence the exomes (traditional gene-coding regions) of 1000 of the high-g GHCA individuals and replicate results for targeted DNA variants using the other 1000 high-g individuals. Few discoveries would have greater impact across the social and life sciences – from genes to brain to behaviour – than identifying genes associated with g.'

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