FGLYP

FLUORINATED SUGARS: CHEMICAL TOOLS FOR THE STUDY OF CARBOHYDRATE-BINDING PROTEINS

 Coordinatore UNIVERSITAT ROVIRA I VIRGILI 

 Organization address address: CARRER DE ESCORXADOR
city: TARRAGONA
postcode: 43003

contact info
Titolo: Prof.
Nome: Rosa
Cognome: Solà I Alberich
Email: send email
Telefono: +34 977 558002

 Nazionalità Coordinatore Spain [ES]
 Totale costo 75˙000 €
 EC contributo 75˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAT ROVIRA I VIRGILI

 Organization address address: CARRER DE ESCORXADOR
city: TARRAGONA
postcode: 43003

contact info
Titolo: Prof.
Nome: Rosa
Cognome: Solà I Alberich
Email: send email
Telefono: +34 977 558002

ES (TARRAGONA) coordinator 75˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

glycoconjugates    nmr    proteins    carbohydrates    preparation    acids    lipids    amino    molecules    synthesis    peptides    corresponding    fluorinated    mainly    carbohydrate   

 Obiettivo del progetto (Objective)

'This project focuses on the preparation of potentially biologically active fluorinated glycoconjugates (mainly lipids, amino acids, peptides and eventually proteins) and also to explore the biological and biophysical properties of these molecules in vitro and in living cells that are decorated with these unnatural fluorinated elements on their surfaces. For this purpose, the project will first focus on the preparation of a range of fluorinated carbohydrates and lipids with configurations related to those recognized by lectins. The synthesis of fluorinated carbohydrates and lipids will be carried out using already established procedures and by developing new procedures based on carbohydrate chemistry or asymmetric synthesis. The next step will consist of attaching the prepared fluorinated materials to the corresponding aglycons, amino acids, peptides or proteins (in the case of F-carbohydrates) or to the corresponding sugars in the case of F-lipids. In the second part of the project, the conformation of these F-glycoconjugates will be studied using leading spectroscopic techniques (mainly 19F STD-NMR, X-ray, etc.). This will provide valuable information on how these molecules might interact with target proteins and receptors. Next, those constructs with most interesting properties will be employed for proteomic analysis as multifunctional affinity-based probes, to screen, detect and isolate carbohydrate-binding proteins with/without enzymatic activity. Finally, the sensitivity and the absence of a F background signal in 19F NMR will be used to study the metabolic profile of those F-glycoconjugates (by 19F NMR) and establish correlations between alteration of biosynthetic pathways, biodistribution, metabolite concentrations, immune response and disease.'

Altri progetti dello stesso programma (FP7-PEOPLE)

SRSR (2013)

Deciphering small RNA mechanisms during sexual reproduction in Arabidopsis

Read More  

ATTRACT (2009)

Advanced Teaching and TRaining for Adoptive Cell Therapy

Read More  

HYMECAV (2014)

Metal Hybrid Cavities

Read More