EXTREMOPHILE MAMMAL

Molecular exploitation of an extremophile mammal

 Coordinatore MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 2˙498˙960 €
 EC contributo 2˙498˙960 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-ADG_20110310
 Funding Scheme ERC-AG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2017-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT

 Organization address address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125

contact info
Titolo: Dr.
Nome: Ioannis
Cognome: Legouras
Email: send email
Telefono: 493094000000
Fax: 493094000000

DE (BERLIN) hostInstitution 2˙498˙960.00
2    MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT

 Organization address address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125

contact info
Titolo: Prof.
Nome: Gary Richard
Cognome: Lewin
Email: send email
Telefono: 493094000000
Fax: 493094000000

DE (BERLIN) hostInstitution 2˙498˙960.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

life    variants    functionally    rats    gene    species    lack    physiology    acid    mole    naked    extreme    rodent    physiological    rat   

 Obiettivo del progetto (Objective)

'The African naked mole-rat (Heterocephalus glaber) is an unusual rodent species that has evolved physiological strategies to adapt to an extreme ecological niche. It is the only poikilothermic mammal (cold-blooded), has an extraordinarily long life span for its small size (in excess of 30 years) and lives in large colonies organized like those of termites (eusocial). We have shown that naked mole-rats lack physiological attributes thought essential and protective for most other animal species. For example, severe tissue acidosis is life threatening as well as painful and yet naked mole-rats completely lack behavioral sensitivity to acid and sensory neurons are not activated by protons in this species. Here we will identify functionally important naked mole-rat gene variants that may account for aspects of the extreme physiology in this species. We have already identified candidate naked mole-rat-genes whose altered function, compared to other mammals, may account for acid insensitivity, lack of pain sensitization and poikilothermy in this species. These gene variants will be functionally characterized by replacing the mouse gene with a naked-mole rat variant using molecular genetic techniques. In addition we will use next generation sequencing to identify further naked mole-rat gene variants. These studies will allow us to learn how evolution selected for functionally significant gene variants that can radically alter normal physiology in the context of a rodent genome.'

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