MORPHOGRAD

Biophysical study of the coupling between cell proliferation and morphogen gradients

 Coordinatore UNIVERSITE DE GENEVE 

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Marcos
Cognome: González-Gaitán
Email: send email
Telefono: +41 22 37 96461
Fax: +41 22 37 96470

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 184˙709 €
 EC contributo 184˙709 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-02-01   -   2015-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Marcos
Cognome: González-Gaitán
Email: send email
Telefono: +41 22 37 96461
Fax: +41 22 37 96470

CH (GENEVE) coordinator 184˙709.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pathway    divide    accordingly    cell    dpp    wing    read    hypothesis    cells    thanks    temporal    signalling    hippo    drosophila    regulate    gradient    differences    cycle    tumour   

 Obiettivo del progetto (Objective)

As well as controlling patterning, morphogens such as the Drosophila BMP homolog Decapentaplegic (Dpp) also regulate growth during development, but how they do so remains largely unclear. One privileged hypothesis, called the steepness hypothesis, suggests that cells in a tissue read spatial differences in the morphogen gradient and divide accordingly. However, the host lab recently discovered a novel mechanism by which the Dpp gradient controls growth: in the Drosophila wing disc, cells are able to read temporal differences in the Dpp gradient and regulate their cell cycle accordingly. More precisely, cells divide when their Dpp signalling level has increased by a constant percentage alpha since the start of their current cell cycle. Using biophysical methods, I will expand this work and study the molecular mechanisms coupling proliferation control with temporal changes in the Dpp gradient. I will generate cell cycle biosensors in order to monitor cell cycle parameters and their evolution throughout wing development, using fixed samples but also thanks to live imaging. I will also analyse the cell cycle and Dpp gradient characteristics in different tumourigenic conditions, in the hope to uncover general principles governing tumour formation. Finally, as several interactions have been uncovered between Dpp signalling and the tumour suppressor Hippo pathway, I will assess thanks to cell culture as well as in vivo assays whether the Hippo pathway could mediate the continued sensitivity of cells to the temporal Dpp signalling increase throughout development.

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