RECOIN

Studying the Mechanisms of Enhanced Pathogenesis in Polymicrobial Respiratory Co-Infection

 Coordinatore THE UNIVERSITY OF BIRMINGHAM 

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Ms.
Nome: May
Cognome: Chung
Email: send email
Telefono: 441214000000
Fax: 441214000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 209˙033 €
 EC contributo 209˙033 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-03-07   -   2014-03-06

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Ms.
Nome: May
Cognome: Chung
Email: send email
Telefono: 441214000000
Fax: 441214000000

UK (BIRMINGHAM) coordinator 209˙033.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

viral    adhesion    bacteria    infection    bacterial    respiratory    individual    synergy    events    co    influenza    infections    cells   

 Obiettivo del progetto (Objective)

'Illness caused by respiratory infection with Influenza viruses represents a vast healthcare and economic burden in the modern world. It is well established that respiratory viral infections are often complicated by secondary bacterial infections, however co-infection often causes a much more severe disease than either microorganism would individually. The mechanisms behind this synergy are not fully understood, however adhesion; the first step in bacterial colonisation, has been shown to be enhanced in virus-infected cells. We hypothesise that early events following Influenza infection of lung epithelium promote bacterial adhesion by regulating primary receptor trafficking and may offer new targets for anti-bacterial intervention.

The aims of this project are to dynamically characterise the adhesion of individual bacteria to airway epithelial cells with high-temporal and spatial resolution and to study the effects of Influenza A co-infection on this phenomenon. We will develop new protocols to track bacteria in three dimensions in order to study individual adhesion events and will calculate diffusion modes during and after bacterial contact with the host cells. These studies will provide novel insights into the processes underlying bacterial adhesion and will explore the mechanism of viral-bacterial synergy to discover new targets for the prevention and treatment of serious respiratory infections.'

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