VIROMA

Design of a versatile and fast colloidal sensor based on virus modified particles

 Coordinatore ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES 

 Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182
city: SAN SEBASTIAN
postcode: 20009

contact info
Titolo: Mr.
Nome: Alfonso
Cognome: Egaña
Email: send email
Telefono: +34 943005300
Fax: 34943005301

 Nazionalità Coordinatore Spain [ES]
 Totale costo 1˙145˙078 €
 EC contributo 1˙145˙078 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IAPP
 Funding Scheme MC-IAPP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-11-01   -   2017-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES

 Organization address address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182
city: SAN SEBASTIAN
postcode: 20009

contact info
Titolo: Mr.
Nome: Alfonso
Cognome: Egaña
Email: send email
Telefono: +34 943005300
Fax: 34943005301

ES (SAN SEBASTIAN) coordinator 376˙437.38
2    Surflay Nanotec GmbH

 Organization address address: SCHWARZSCHILDSTRASSE 8
city: Berlin
postcode: 12489

contact info
Titolo: Dr.
Nome: Claudia
Cognome: Aldenhoven
Email: send email
Telefono: +49 3063921764
Fax: +49 30 63921767

DE (Berlin) participant 541˙272.30
3    UNIVERSITAET LEIPZIG

 Organization address address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109

contact info
Titolo: Prof.
Nome: Edwin
Cognome: Donath
Email: send email
Telefono: +49 341 9715704

DE (LEIPZIG) participant 227˙369.02

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

virosome    virus    analytes    layer    viroma    colloidal    employed    bead    recognition    larger    suitable    detection    beads    size    small    molecules    particles   

 Obiettivo del progetto (Objective)

'Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such systems are fast and sensitive, and require due to multiplexing and single particle based fluorometric read-outs only a very small amount of sample for analysis and is, suitable for high throughput analysis. The uniqueness of the approach developed in VIROMA is that the virus particles will retain their specific recognition properties provided by the virus capsides and transfer this specificity to the colloidal carrier. Moreover, the possibility of assembling different virus nanoparticles and virosomes on top of the colloids will result in particles with multiple recognition capabilities, going a step ahead nature.

Depending on the analytes size two different detection mechanisms will be employed. If the analyte is a larger peptide or protein, a sandwich immunoassay can be employed with the capture antibody integrated into the virosome and transferred to the bead by means of virosome-membrane fusion. The fluorescence will be recorded with a flowcytometry using a colloidal dispersion of the beads or a laser scanning microscope if the beads are immobilized on a chip. As an example, we will assemble beads capable of detecting troponin, a standard marker for myocardial infarction. For small molecule s specific receptor molecules will be designed for a competitive assay. The project involves a synergic collaboration between two academic institutions: CIC biomaGUNE and the University of Leipzig with the company SURFLAY.'

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