CAT. ASYMM. LITHIUM

Catalytic Asymmetric C-C bond formation with Organo-Lithium reagents

Coordinatore	RIJKSUNIVERSITEIT GRONINGEN    more  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Dr. Nome: H.D. Cognome: Veldhuis Email: send email Telefono: +31 50 3634235 Fax: +31 50 3634296
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	183˙805 €
EC contributo	183˙805 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2014-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN  Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP contact info Titolo: Dr. Nome: H.D. Cognome: Veldhuis Email: send email Telefono: +31 50 3634235 Fax: +31 50 3634296	NL (GRONINGEN)	coordinator	183˙805.80

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 Obiettivo del progetto (Objective)

'Carbon–carbon bond formation is at the hearth of chemistry and the development of new methodology for catalytic enantioselective C-C bond formation continues to be a major challenge for synthesis. After more than 80 years since the introduction of organolithium reagents, no general, highly enantioselective and practical catalytic C-C bond formation with organolithium reagents exists. In preliminary studies, Feringa´s group have recently discovered that simple alkyl lithium reagents (MeLi, n-BuLi) yield excellent enantioselectivities in copper catalyzed asymmetric allylic alkylation. The subject of the project is the development of new methodologies for highly asymmetric catalyzed C-C bond formation using organolithium reagents. In this research project will try to accomplish the catalytic asymmetric allylic substitution with aryllithium reagents, catalytic asymmetric vinylation of allylic halides and the development of other highly desirable transformations (like the asymmetric formation of chiral quaternary centers via allylic substitution or allyllic alkylation with secondary alkyl lithium reagents). The methodology will be explored in a number of challenging transformations outlined above and the catalysts optimized through chiral ligand screening and optimization of reaction parameters.'