LAB-SMART

"Lewis Acidic Borocations: improving Suzuki couplings, Material synthesis, Alkylation and Radical Transformations"

Coordinatore	THE UNIVERSITY OF MANCHESTER    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙267˙160 €
EC contributo	1˙267˙160 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111012
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2017-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Dr. Nome: Michael Cognome: Ingleson Email: send email Telefono: 441613000000	UK (MANCHESTER)	hostInstitution	1˙267˙160.50
2	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Ms. Nome: Liz Cognome: Fay Email: send email Telefono: 441613000000	UK (MANCHESTER)	hostInstitution	1˙267˙160.50

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Carbon-carbon bond formation is arguably the most important reaction in synthetic chemistry, exemplified by the award of five noble prizes. The most recent Nobel prize was awarded for the development of palladium catalysed cross coupling, of which Suzuki cross coupling is the most widely applied version in industry and academia and utilizes organo-boronates (RB(OR)2) as the nucleophilic component. The aims of this project are; (i) to simplify the synthesis of organo-boron compounds that are utilized in (a) Suzuki cross coupling and (b) as boron containing materials for organic electronic applications. (ii) Reduce the dependency on expensive and toxic palladium by a) extending the Friedel Crafts C-C bond forming reaction to broad scope, electrophilic trifluoromethylation and electrophilic arylation (b) generating and applying efficient iron catalysts in an iron analogue of the Suzuki Reaction.

To achieve each of our aims we will utilise the unique properties of electrophilic borocations. Previously we have used boro-cations that combine a coordinatively unsaturated and electrophilic boron centre with a ‘masked’ form of a strong base to develop fundamentally new reactivity. These borocations enabled the sequential one pot activation of a substrate by a strong Lewis acid (the boro-cation) and then release of the masked Lewis base for a subsequent step (e.g., deprotonation). This concept of a boron reagent enabling sequential reactivity by subsequent dissociation of a group is a continual theme through this proposal. This property of borocations will be combined with appropriate leaving groups on the nucleophile to tackle the important challenges outlined above. Key to expanding the synthetic utility is design of the borocation to enable the release not only of a neutral Lewis base (for direct borylation, including the synthesis of RB(OR)2) but also an anionic group (for arylation/alkenylation) or a cationic moiety (for alkylation).'