RETRAIN

REwiring the nucleus TowaRds plant ImmuNity

 Coordinatore UNIVERSITY OF DUNDEE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 1˙393˙084 €
 EC contributo 1˙393˙084 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111109
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-01-01   -   2017-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF DUNDEE

 Organization address address: Nethergate
city: DUNDEE
postcode: DD1 4HN

contact info
Titolo: Dr.
Nome: Edgar
Cognome: Huitema
Email: send email
Telefono: 441383000000

UK (DUNDEE) hostInstitution 1˙393˙084.00
2    UNIVERSITY OF DUNDEE

 Organization address address: Nethergate
city: DUNDEE
postcode: DD1 4HN

contact info
Titolo: Dr.
Nome: Kathryn
Cognome: Williamson
Email: send email
Telefono: +44 1382 388340

UK (DUNDEE) hostInstitution 1˙393˙084.00

Mappa


 Word cloud

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outcomes    proteome    proteins    components    identification    effector    host    infection    nucleus    synthetic    nuclear    immune    induced    pathogen    then    interactions    immunity    signalling    gene    effectors    microbes   

 Obiettivo del progetto (Objective)

'Plant pathogenic microbes cause significant economic damage to global food crop production systems. Pathogens are specialised microbes that manipulate the host defense circuitry to suppress immunity and promote virulence. Interestingly, many of the processes that determine immunity or susceptible interactions, take place in the host nucleus. With the identification of vast repertoires of (nuclear) secreted pathogen proteins (effectors) and host signaling components that extert their functions in the nucleus, this host compartment is now considered an important interface where outcomes are decided.

This proposal aims to unravel the molecular mechanisms that underpin infection outcomes in the nucleus. A powerfull approach that will combine quantitative proteomics with gene expression analyses will be used to (i) detect pathogen effectors in the host nucleus in situ and (ii) identify changes in the nuclear proteome during infection. I will then use Yeast two Hybrid and immunoprecipitation to identify effector host targets before placing these components in a nuclear immune signalling context. New information on effector-induced changes in the host nuclear proteome coupled to immune signalling, will then be used to rationalise implementation of two synthetic approaches towards resistance.

I will design synthetic (non)host targets that are immune to effector induced modifications and function towards immunity. In addition, identification of key effectors and targets will be used to design new R-gene like specificities, embodied in synthetic Nucleotide-Binding Leucine Rich Repeat proteins (sNB-LRR). Overall, this work will impact studies on host-microbe interactions and importantly, will provide proof of concept for two new synthetic breeding strategies in plants.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

DROSOPIRNAS (2010)

The piRNA pathway in the Drosophila germline a small RNA based genome immune system

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TRANSFER-LEARNING (2014)

Transfer Learning within and between brains

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FOUNDMED (2012)

Foundations in medieval societies: Cross-cultural comparisons

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