PHENORAT

EID on the advanced science and technology of rat models for neurodegenerative diseases

 Coordinatore EBERHARD KARLS UNIVERSITAET TUEBINGEN 

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Dr.
Nome: Holm
Cognome: Graessner
Email: send email
Telefono: +49 7071 2972285

 Nazionalità Coordinatore Germany [DE]
 Totale costo 924˙516 €
 EC contributo 924˙516 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-11-01   -   2016-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Dr.
Nome: Holm
Cognome: Graessner
Email: send email
Telefono: +49 7071 2972285

DE (TUEBINGEN) coordinator 498˙313.88
2    NOLDUS INFORMATION TECHNOLOGY BV

 Organization address address: NIEUWE KANAAL 5
city: WAGENINGEN
postcode: 6709 PA

contact info
Titolo: Dr.
Nome: Lucas
Cognome: Noldus
Email: send email
Telefono: +31 317 473300

NL (WAGENINGEN) participant 426˙202.90

Mappa


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excellent    clinical    rat    university    hd    transgenic    models    behavioural    read    sca    model   

 Obiettivo del progetto (Objective)

'One of the most important bottlenecks for finding more effective drugs for brain disorders is the development of model systems that translate to human pathology and are predictive of clinical efficacy. To address this bottleneck PhenoRat will focus on the generation, characterisation and validation of transgenic rat models of two neurodegenerative diseases: Huntington disease (HD) and spinocerebellar ataxia type 17 (SCA17). For this purpose we have assembled a unique consortium in which industry (Noldus Information Technology and Delta Phenomics), academia (University of Tuebingen), and a university-related foundation for entrepreneurship (StartLife) will work closely together to achieve both organization of an excellent training program and excellent research projects with a pronounced focus on intersectoral doctoral education and transfer of knowledge. Two rat models, one already established model for SCA17 and one to be newly generated knock-in rat model of HD, will be behaviourally characterized using a unique integrated system based on video tracking and operant testing in a home cage situation. In addition, innovative behavioural paradigms will be developed to test for the cognitive and emotional impairments typically seen in SCA17 and HD. These findings will be extended with more sophisticated methods to assess fine motor coordination and gait abnormalities. Besides traditional methods of analysis of behavioural data, new statistical methods will be developed to enable behavioural classification of transgenic and wild type animals. This will enable the detection of early onset of specific symptoms and provide read-out parameters in pre-clinical studies applying novel substances for the treatment of HD and SCA17. Last but not least these read-outs will be validated in a gene therapy study with SCA17 rats using Antisense Oligonucleotides (AONs) against the PolyQ stretch of TBP.'

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