TANDEM

"Concurrent Tuberculosis and Diabetes Mellitus; unraveling the causal link, and improving care"

 Coordinatore LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE 

 Organization address address: KEPPEL STREET
city: LONDON
postcode: WC1E7HT

contact info
Titolo: Mr.
Nome: Chris
Cognome: Andrews
Email: send email
Telefono: +44 20 7927 2509

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 7˙872˙461 €
 EC contributo 5˙998˙496 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-02-01   -   2017-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

 Organization address address: KEPPEL STREET
city: LONDON
postcode: WC1E7HT

contact info
Titolo: Mr.
Nome: Chris
Cognome: Andrews
Email: send email
Telefono: +44 20 7927 2509

UK (LONDON) coordinator 864˙577.40
2    UNIVERSITAS PAJAJARAN

 Organization address address: JALAN RAYA BANDUNG 35
city: SUMEDANG
postcode: 45363

contact info
Titolo: Dr.
Nome: Bachti
Cognome: Alisjahbana
Email: send email
Telefono: +62 22 2038218
Fax: +62 22 2033915

ID (SUMEDANG) participant 747˙781.00
3    STICHTING KATHOLIEKE UNIVERSITEIT

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Mr.
Nome: Wim
Cognome: Van Oijen
Email: send email
Telefono: +31 24 3618937
Fax: +31 24 3540529

NL (NIJMEGEN) participant 739˙953.00
4    STELLENBOSCH UNIVERSITY

 Organization address address: RYNEVELD STREET WILCOCKS BUILDING 2035
city: STELLENBOSCH
postcode: 7601

contact info
Titolo: Prof.
Nome: Gerhard
Cognome: Walzl
Email: send email
Telefono: +27 21 938 9158
Fax: +27 21 938 9863

ZA (STELLENBOSCH) participant 713˙040.80
5    UNIVERSITATEA DE MEDICINA SI FARMACIE DIN CRAIOVA

 Organization address address: PETRU RARES 2
city: CRAIOVA
postcode: 200349

contact info
Titolo: Mr.
Nome: Mihai
Cognome: Caragea
Email: send email
Telefono: +40 723207593
Fax: +40 251 593077

RO (CRAIOVA) participant 487˙513.20
6    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Robert
Cognome: Golinski
Email: send email
Telefono: +49 30 28460555
Fax: +49 30 28460501

DE (MUENCHEN) participant 485˙115.00
7    UNIVERSIDAD PERUANA CAYETANO HEREDIA

 Organization address address: HONORIO DELGADO 430
city: LIMA
postcode: 31

contact info
Titolo: Dr.
Nome: Maria
Cognome: Rivera
Email: send email
Telefono: +51 1 319 2271

PE (LIMA) participant 401˙311.20
8    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Mrs.
Nome: Johanna M.
Cognome: Van Apeldoorn
Email: send email
Telefono: +31 50 3633040

NL (GRONINGEN) participant 395˙454.40
9    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Mr.
Nome: Emiel
Cognome: Schaap
Email: send email
Telefono: +31 71 526 4780
Fax: +31 71 526 6941

NL (LEIDEN) participant 373˙080.00
10    EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

 Organization address address: Science Park 1, Stuhlsatzenhausweg 69
city: SAARBRUECKEN
postcode: 66123

contact info
Titolo: Ms.
Nome: Hannah
Cognome: Weber
Email: send email
Telefono: +49 681 95923377

DE (SAARBRUECKEN) participant 296˙400.00
11    UNIVERSITY OF OTAGO

 Organization address address: SAINT DAVID STREET
city: DUNEDIN
postcode: 9054

contact info
Titolo: Prof.
Nome: Colin
Cognome: Campbell-Hunt
Email: send email
Telefono: +64 3 479 8905
Fax: +64 3 479 7657

NZ (DUNEDIN) participant 296˙028.00
12    ST GEORGE'S HOSPITAL MEDICAL SCHOOL

 Organization address address: Cranmer Terrace
city: LONDON
postcode: SW17 0RE

contact info
Titolo: Ms.
Nome: Melanie
Cognome: Monteiro
Email: send email
Telefono: +44 208 725 5024
Fax: +44 208 725 0312

UK (LONDON) participant 198˙242.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

treatment    underlying    combined    effect    tb    link    endemic    we    susceptibility    outcome    data    dm    diabetes    countries    determine    tuberculosis    patients   

 Obiettivo del progetto (Objective)

'Diabetes (DM) triples the risk of developing tuberculosis (TB). Consequently, the alarming growth of type 2 DM in TB endemic countries and among people originating from TB-endemic countries poses a serious threat to global TB control. This project addresses the scarce evidence for many of the recently advocated guidelines for care and control of TB and DM, as well as our lack of understanding of the mechanisms underlying the effect of DM on TB susceptibility and treatment outcome. We will use a comprehensive and integrated approach combining clinical, epidemiological and cutting edge expertise in laboratory sciences, bringing together a multi-disciplinary consortium linking field sites in Romania, Peru, South Africa and Indonesia, with leading laboratories in Germany, United Kingdom and the Netherlands. We will define the optimal and most cost-effective ways of screening TB patients for DM diabetes, and determine the prevalence of DM among TB patients and of TB in DM patients in the four countries. With regard to treatment, we will determine the level of DM management required during and after TB treatment, the safety and pharmacokinetics of metformin when combined with rifampicin, and the effect of hyperglycemia control on TB treatment outcome. To help establish the cellular basis and immunological pathways underlying the link between DM and TB we will provide new data on: gene expression data of TB patients with and without DM; ex vivo and in vitro Mycobacterium tuberculosis stimulation data of different cell types, including macrophage subsets and adipocytes in the presence of high glucose and insulin; data regarding the role of common and more rare genetic variants in the combined susceptibility to TB and type 2 DM; and relevant functional genomics experiments. In summary, this project is expected to have significant impact both in improving basic knowledge on the link between TB and DM, as well as on prevention, therapeutic management and prognosis of TB-DM.'

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