SYSMEDIBD

Systems medicine of chronic inflammatory bowel disease

 Coordinatore THE UNIVERSITY OF MANCHESTER 

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Mrs.
Nome: Claire
Cognome: Faichnie
Email: send email
Telefono: +44 161 275 8796
Fax: +44 161 2758796

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 15˙727˙548 €
 EC contributo 11˙999˙998 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-1
 Funding Scheme CP-IP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-12-01   -   2017-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Mrs.
Nome: Claire
Cognome: Faichnie
Email: send email
Telefono: +44 161 275 8796
Fax: +44 161 2758796

UK (MANCHESTER) coordinator 3˙462˙748.00
2    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

 Organization address address: OLSHAUSENSTRASSE 40
city: KIEL
postcode: 24118

contact info
Titolo: Ms.
Nome: Susanne
Cognome: Neufeldt
Email: send email
Telefono: 494319000000
Fax: 494319000000

DE (KIEL) participant 1˙493˙400.00
3    UNIVERSITEIT MAASTRICHT

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Dr.
Nome: Joseh I.H.
Cognome: Janssen
Email: send email
Telefono: 31433881961
Fax: 31433670286

NL (MAASTRICHT) participant 995˙434.00
4    UNIVERSITAETSKLINIKUM AACHEN

 Organization address address: Pauwelsstrasse 30
city: AACHEN
postcode: 52074

contact info
Titolo: Mr.
Nome: Volker
Cognome: Legewie
Email: send email
Telefono: +49 241 80 88494
Fax: +49 241 80 82051

DE (AACHEN) participant 994˙800.00
5    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Ms.
Nome: Jenny
Cognome: Lawson
Email: send email
Telefono: 441518000000

UK (LIVERPOOL) participant 992˙250.00
6    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Dr.
Nome: Peter
Cognome: Hedges
Email: send email
Telefono: 442477000000
Fax: +44 24765 24991

UK (COVENTRY) participant 942˙410.00
7    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Ina
Cognome: Krischek
Email: send email
Telefono: +49 6221 42 2700
Fax: +49 6221 42 2708

DE (HEIDELBERG) participant 849˙997.00
8    THE HEBREW UNIVERSITY OF JERUSALEM.

 Organization address address: GIVAT RAM CAMPUS
city: JERUSALEM
postcode: 91904

contact info
Titolo: Ms.
Nome: Jane
Cognome: Turner
Email: send email
Telefono: +972 2 6586676
Fax: +972 7 22447007

IL (JERUSALEM) participant 749˙999.00
9    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O

 Organization address address: Oskar-von-Miller-Ring 29
city: MUENCHEN
postcode: 80333

contact info
Titolo: Mrs.
Nome: Birgit
Cognome: Fuchs
Email: send email
Telefono: 498929000000
Fax: 498929000000

DE (MUENCHEN) participant 501˙000.00
10    LIFEGLIMMER GMBH

 Organization address address: MARKELSTRASSE 39 A
city: BERLIN
postcode: 12163

contact info
Titolo: Dr.
Nome: Susanne
Cognome: Hollmann
Email: send email
Telefono: 493022000000

DE (BERLIN) participant 500˙000.00
11    GENEXPLAIN GMBH

 Organization address address: AM EXER 10 B
city: WOLFENBUTTEL
postcode: 38302

contact info
Titolo: Dr.
Nome: Holger
Cognome: Michael
Email: send email
Telefono: +49 533199220012
Fax: +49 533199220022

DE (WOLFENBUTTEL) participant 499˙960.00
12    THE UNIVERSITY OF AUCKLAND

 Organization address address: PRINCES STREET 24
city: AUCKLAND
postcode: 1142

contact info
Titolo: Mrs.
Nome: Julia
Cognome: Zhu
Email: send email
Telefono: 6493737599

NZ (AUCKLAND) participant 18˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

dependent    microscopy    inflammatory    morbidities    validated    databases    nf    co    cell    patients    human    biological    oscillating    small    tissue    model    bowel    disease       molecules    gut    ibd    models    animal    interfering    oscillation    treatments    experimental    verify    nfkb   

 Obiettivo del progetto (Objective)

'Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillation in chronic inflammatory bowel diseases in animal models and patient cohorts with immunosuppressive treatments and controls. The aim is to build an experimentally validated model the NfkB oscillation in 4D within the gut tissue. Dynamic, experimental validation will be done for various types of cells in the gut by a combination of methods, including single-cell based transcriptomics, multi-photon microscopy and time-dependent, multi-component profiling. The validated model framework will enable searching for critical components of the NfB oscillation and to assess their relevance for the disease in patients. Interfering with the oscillation of biological pathways may provide new possibilities to influence biological processes like inflammation. Hence, we will search (assisted by the models and databases developed) for small molecules interfering with the NfkB oscillation in chemical databases and validate selected candidates in experimental systems. To this end, we will use cell lines with the correct indicator constructs using high content microscopy. To better translate the findings in animal models to patients, we will use a mouse model with transplanted human tissue so that we can verify the mathematical model in human tissue and verify functionality of small molecules in vivo. Owing to its systems, highly focused approach, the project will generate substantial insights into key mechanisms underlying IBD and will provide ways to modulate the oscillatory behavior of the NfB in IBD and IBD-dependent co-morbidities.'

Introduzione (Teaser)

European experts in the field of clinical and experimental immunology are studying NF-kappa-B signalling dynamics and oscillations in inflammatory bowel disease (IBD). The long-term goal is to identify biomarkers that could be exploited for disease prediction, diagnosis and stratification.

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