OPTOLOCO

Dynamic sensory-motor integration in spinal circuits

 Coordinatore INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FONDATION 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore France [FR]
 Totale costo 1˙498˙500 €
 EC contributo 1˙498˙500 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111109
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-02-01   -   2018-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FONDATION

 Organization address address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013

contact info
Titolo: Dr.
Nome: Claire Julie Liliane
Cognome: Wyart
Email: send email
Telefono: 33157274310
Fax: 33157274027

FR (PARIS) hostInstitution 1˙498˙500.00
2    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FONDATION

 Organization address address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013

contact info
Titolo: Ms.
Nome: Iwona
Cognome: Jablonska
Email: send email
Telefono: +33 157274745
Fax: 33157274027

FR (PARIS) hostInstitution 1˙498˙500.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

circuits    patterns    output    relies    proprioceptive    motor    shape    cycle    animals    moving    spinal    sensory    inputs    locomotion   

 Obiettivo del progetto (Objective)

'Although locomotion may seem effortless, it relies on spinal circuits producing extraordinarily complex patterns of muscle contractions. Graded movements occur over a wide range of amplitudes and frequencies, instantaneously adapting to changes in the environmental or inner state. Locomotion relies on oscillations generated by genetically determined circuits within the spine. Sensory information flowing in the circuits selects and shapes the pattern of motor outputs by triggering, stopping or steering locomotion. Sensory cells connect with ensembles of premotor neurons. Challenging studies in moving animals revealed that complex proprioceptive inputs were timed to the locomotor cycle. But when are mechano, chemo, and thermosensory inputs active in moving animals? And how are they integrated by spinal cell assemblies to alter motor patterns? I propose to study sensory-motor integration in a simple genetic model organism to address these crucial points. The transparency of the zebrafish larva enables measuring and manipulating sensory inputs in moving animals. Recently, we developed in vivo optogenetic approaches for probing spinal circuits. We identified a novel sensory pathway in vertebrates which interfaces spinal circuits with the cerebrospinal fluid. We demonstrated that remote activation of these inputs triggered slow locomotion. We will now combine optogenetics, population imaging, electrophysiology and quantitative behavioural analysis to dissect this novel proprioceptive function (Aim 1). We will extend our approach to other senses to examine when specific sensory inputs are recruited in the swimming cycle and how they dynamically shape motor output in moving animals (Aim 2). We will unravel how sensory inputs select motor patterns at the circuit level (Aim 3). Our studies will contribute to a fundamental question: how do circuits integrate local sensory information to shape complex output patterns?'

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