CDGMP

"Time, space and speed: cdGMP signaling in cell behavior and reproduction."

 Coordinatore UNIVERSITAET BASEL 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 2˙496˙000 €
 EC contributo 2˙496˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-ADG_20120314
 Funding Scheme ERC-AG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-05-01   -   2018-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Dr.
Nome: Kurt
Cognome: Kamber
Email: send email
Telefono: +41 61 267 28 33

CH (BASEL) hostInstitution 2˙496˙000.00
2    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Urs
Cognome: Jenal
Email: send email
Telefono: 41612672135
Fax: 41612672118

CH (BASEL) hostInstitution 2˙496˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

network    bacterial    messenger    cellular    surface    signaling    molecular    cell    details    quantitatively    biofilm    motile    bacteria    dynamics    describe    communities    asymmetric    cdgmp   

 Obiettivo del progetto (Objective)

'Bacterial biofilms are the primary cause of chronic infections and of resulting infection relapses. To be able to interfere with bacterial persistence it is vital to understand the molecular details of biofilm formation and to define how motile planktonic cells transit into surface-grown communities. The nucleotide second messenger cyclic di-guanosinemonophosphate (cdGMP) has emerged as a central regulatory factor governing bacterial surface adaptation and biofilm formation. Although cdGMP signaling may well represent the Achilles heel of bacterial communities, cdGMP networks in bacterial pathogens are exquisitely complex and an integrated cellular system to uncover the details of cdGMP dynamics is missing. To quantitatively describe cdGMP signaling we propose to exploit Caulobacter crescentus, an organism with a simple bimodal life-style that integrates the sessile-motile switch into its asymmetric division cycle. We aim to: 1) identify the role and regulation of all diguanylate cyclases and phosphodiesterases that contribute to the asymmetric cellular program with the goal to model the temporal and spatial distribution of cdGMP during development; 2) identify and characterize cdGMP effectors, their downstream targets and cellular pathways; 3) elucidate how cdGMP coordinates cell differentiation with cell growth and propagation; 4) unravel the role of cdGMP as an allosteric regulator in mechanosensation and in rapid adaptation of bacteria to growth on surfaces; 5) develop novel tools to quantitatively describe cdGMP network dynamics as the basis for mathematical modeling that provides the predictive power to experimentally test and refine important network parameters. We propose a multidisciplinary research program at the forefront of bacterial signal transduction that will provide the molecular and conceptual framework for a rapidly growing research field of second messenger signaling in pathogenic bacteria.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

INTERCOCOS (2011)

Interdisciplinary research: Connecting complex plasmas with colloidal dispersions

Read More  

PREMESOR (2012)

Predisposed mechanisms for social orienting: A comparative neuro-cognitive approach

Read More  

INTRACELLTB (2010)

A Chemical Genomics Approach of Intracellular Mycobacterium tuberculosis Towards Defining Specific Host Pathogen Interactions

Read More