GUVS-3G

Smart photo-activable devices based in plasmonic nanoparticles: Microfluidic-assisted engineering of a third generation of lipid vesicles

 Coordinatore UNIVERSIDAD COMPLUTENSE DE MADRID 

 Organization address address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040

contact info
Titolo: Mrs.
Nome: Maribel
Cognome: Rodríguez Villa
Email: send email
Telefono: 34913946376
Fax: 34913946382

 Nazionalità Coordinatore Spain [ES]
 Totale costo 254˙925 €
 EC contributo 254˙925 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-09-01   -   2016-12-21

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID

 Organization address address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040

contact info
Titolo: Mrs.
Nome: Maribel
Cognome: Rodríguez Villa
Email: send email
Telefono: 34913946376
Fax: 34913946382

ES (MADRID) coordinator 254˙925.90

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

giant    vesicles    encapsulation    nanoparticles    cell    smart    permeability    engineering    membrane    inducible    osmotic    lipid   

 Obiettivo del progetto (Objective)

'Giant lipid vesicles can be potentially used as biocompatible carriers with a large lumen cavity adequate for lodging large biomacromolecules in an aqueous compartment. New developments in controlled delivery are strongly troubled by the high polydispersity of the preparations and the limitations in the encapsulation abilities inherent to conventional preparative methods. Engineering smart vesicles with tunable and remotely controllable properties such as permeability, osmotic deformability or inducible instability, necessary for adequate delivery, is indeed a major synthetic challenge. This implies a number of basic operations, which include bilayer assembly, composite membrane stabilization, encapsulation and compartmentalization, a set of procedures requiring a novel approach. For this performance, we propose the use of microfluidic technology and high-speed imagining to design and study the active response to photo-irradiation of smart giant unilamellar lipid vesicles with plasmonic gold nanoparticles embedded in the membrane. Excitation of the surface plasmons of the nanoparticles produces localized heating of the membrane, thus controllable changes in permeability, which could eventually result in an enhanced osmotic-driven flow of solvent across the membrane and cause an overall change in size and shape of the entire vesicle. Using these model systems we will be able to shed light on the physical mechanisms involved in the transference of conformational- to mechanical- energy, which could be relevant to a broad range of scientific problems ranging from the fundamental knowledge in cell biology, concerned by the study of cellular functions such as endo- and exocytosis and cell motility, to applications in drug delivery and material engineering, both enrolled in the development of hybrid materials able to exert nastic motions inducible by external stimuli.'

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