LINCAGE

Investigating the involvement of lincRNAs in aging of haematopoietic stem cells and in haematological malignancies

 Coordinatore UNIVERSITE PARIS DIDEROT - PARIS 7 

 Organization address address: RUE THOMAS MANN 5
city: PARIS
postcode: 75205

contact info
Titolo: Ms.
Nome: Anne-Sophie
Cognome: Réfloc'h
Email: send email
Telefono: +33 157276668
Fax: +33 157276662

 Nazionalità Coordinatore France [FR]
 Totale costo 269˙743 €
 EC contributo 269˙743 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-04-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS DIDEROT - PARIS 7

 Organization address address: RUE THOMAS MANN 5
city: PARIS
postcode: 75205

contact info
Titolo: Ms.
Nome: Anne-Sophie
Cognome: Réfloc'h
Email: send email
Telefono: +33 157276668
Fax: +33 157276662

FR (PARIS) coordinator 269˙743.80

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 Word cloud

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molecules    aml    normal    chromatin    age    class    aging    structure    cells    related    lincrnas    malignancy    hsc   

 Obiettivo del progetto (Objective)

'Changes in chromatin structure are observed during aging and are often a critical step during tumorigenesis. The class of long intergenic non-coding RNAs (lincRNA), has emerged as an important regulator of chromatin structure during normal differentiation, and recently has been implicated in the disregulation of chromatin structure observed in several solid tumours. These lincRNAs could represent an important new class of oncogene. We propose to investigate a potential involvement of lincRNAs in chromatin changes that occur during normal aging of haematopoietic stem cells (HSC), and in acute myeloid leukaemia (AML), an age-related haematological malignancy that is frequently associated with chromatin abnormalities. High-throughput sequencing will be used to compare expression of lincRNAs between young and old HSC, and between AML and normal CD34 cells. Differentially expressed lincRNAs will be functionally investigated by lentiviral-mediated knockdown and overexpression in cell lines and primary cells, and concomitant changes in chromatin structure will be profiled by chromatin immunoprecipitation. It is expected that this project will clarify the general importance of lincRNAs both in normal aging and in an age-related cancer, and could identify novel molecules which are important drivers of malignancy as well as the functional changes associated with HSC aging. As well as being potential prognostic markers and direct targets for therapeutics in AML, these molecules might also be targeted to improve the function of aging HSCs.'

Altri progetti dello stesso programma (FP7-PEOPLE)

EPICENTROMERE (2008)

Determining the Epigenetic Mechanism of Centromere Propagation

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PROTEASE SIGNALING (2009)

Protease signaling in development and disease

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MUSAPH (2007)

Multi-scale analysis of models for phase change

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