TB-VIR

Mycobacterium tuberculosis W-Beijing genetic diversity and differential virulence and host immune responses

 Coordinatore  

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Armelle
Cognome: Barelli
Email: send email
Telefono: +33 5 61 33 60 80
Fax: +33 5 62 17 29 01

 Nazionalità Coordinatore Non specificata
 Totale costo 3˙887˙442 €
 EC contributo 2˙967˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2011-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Armelle
Cognome: Barelli
Email: send email
Telefono: +33 5 61 33 60 80
Fax: +33 5 62 17 29 01

FR (PARIS) coordinator 0.00
2    "RUJIN HOSPITAL, SHANGAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE"

 Organization address address: 197 RUI JIN ER ROAD
city: SHANGHAI
postcode: 200025

contact info
Titolo: Ms.
Nome: Yiping
Cognome: Xu
Email: send email
Telefono: 8621-64370045 ext 665824
Fax: 8621-64333414

CN (SHANGHAI) participant 0.00
3    FUDAN UNIVERSITY

 Organization address address: HANDAN ROAD 220
city: SHANGHAI
postcode: 200433

contact info
Titolo: Prof.
Nome: Xue-Lei
Cognome: Lin
Email: send email
Telefono: 8621-65642484
Fax: 8621-65649267

CN (SHANGHAI) participant 0.00
4    GATC BIOTECH AG

 Organization address address: JAKOB STADLER PLATZ 7
city: KONSTANZ
postcode: 78467

contact info
Nome: Peter
Cognome: Pohl
Email: send email
Telefono: +49-(0)7531-8160-13
Fax: +49-(0)7531-8160-81

DE (KONSTANZ) participant 0.00
5    INSERM - TRANSFERT SA

 Organization address address: Rue Watt 7
city: PARIS
postcode: 75013

contact info
Titolo: Mr.
Nome: Louis
Cognome: Jammayrac
Email: send email
Telefono: -55030069
Fax: -55030128

FR (PARIS) participant 0.00
6    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) participant 0.00
7    INSTITUT PASTEUR KOREA

 Organization address address: "HAWOLGOK DONG, SEONGBUK GU 39-1"
city: SEOUL
postcode: 136 791

contact info
Titolo: Ms.
Nome: Sungeun
Cognome: Kim
Email: send email
Telefono: -3511
Fax: -3429

KR (SEOUL) participant 0.00
8    INTEGRAGEN SA

 Organization address address: RUE HENRI DESBRUERES GENOPOLE 5
city: EVRY
postcode: 91000

contact info
Titolo: Mr.
Nome: Patrick
Cognome: Court
Email: send email
Telefono: +33 160 910 909
Fax: +33 160 910 922

FR (EVRY) participant 0.00
9    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Birgit
Cognome: Gieding
Email: send email
Telefono: +49-30-28460 125
Fax: +49-30-28460 242

DE (MUENCHEN) participant 0.00
10    SHANGAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION

 Organization address address: west Zhongshan Road
city: SHANGAI
postcode: 200336

contact info
Nome: Hangping
Cognome: Yang
Email: send email
Telefono: +86 21 62758710
Fax: x

CN (SHANGAI) participant 0.00
11    UNIVERSIDAD DE ZARAGOZA

 Organization address address: CALLE PEDRO CERBUNA 12
city: Zaragoza
postcode: 50009

contact info
Titolo: Mr.
Nome: Oscar
Cognome: Lopez Lorente
Email: send email
Telefono: 34976761000
Fax: 34976761048

ES (Zaragoza) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

genetic    diversity    mycobacterial       infection    virulence    beijing    strain    genomic    host    responses    lineage       tuberculosis    families    intervention    family    individuals    tb    worldwide   

 Obiettivo del progetto (Objective)

'Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, together with host genetic factors, contribute to such differences between infected individuals. The M. tuberculosis W-Beijing lineage is one of the most successful mycobacterial families, in terms of morbidity and mortality. This lineage has been detected almost worldwide. The predominance of the W-Beijing lineage probably results from genetic advantages, including unidentified virulence factors and the induction/modification of specific host responses not yet thoroughly investigated. This project aims to unravel the links between differential host responses to M. tuberculosis infection and mycobacterial genetic diversity and virulence at the global genomic and post-genomic levels within the W-Beijing family, and between the W-Beijing family and other M. tuberculosis families, in order to improve our understanding of the epidemiological success of this particular lineage. Overall, this work will provide the scientific and clinical community with pioneering research and novel information increasing our understanding of the impact of M. tuberculosis strain diversity on virulence, immune response and pathology. This project will complement and expand the efforts of several internationally recognized laboratories to unveil new genotype-phenotype associations by integrating complex phenotypic data and information about mycobacterial genetic diversity.'

Introduzione (Teaser)

Tuberculosis (TB) remains a serious health issue worldwide with nearly 1.7 million related deaths every year. The urgent requirement for intervention drove researchers of the TB-VIR project to study the genetics of Mycobacterium tuberculosis (MTB) virulence.

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