CARDIOGEN

The Molecular Mechanisms of Heart Regeneration

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Jocelyn
Cognome: Mere
Email: send email
Telefono: +33 4 67 34 35 35
Fax: +33 4 67 04 32 36

 Nazionalità Coordinatore France [FR]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-03-01   -   2017-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Jocelyn
Cognome: Mere
Email: send email
Telefono: +33 4 67 34 35 35
Fax: +33 4 67 04 32 36

FR (PARIS) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

genes    regenerating    candidates    cardiomyocytes    heart    shown    indicate    determine    mammalian    data    regeneration    proliferation    previously    cardiomyocyte    zebrafish    microarray    models    mammals   

 Obiettivo del progetto (Objective)

'Adult zebrafish are capable of completely regenerating their heart after an extensive insult. Previously, we determined that the regenerated myocardium was produced by the proliferation of existing cardiomyocytes and not, as had previously been reported, by stem/progenitor cells. Analysis of regenerating hearts shows that soon after injury cardiomyocytes detach from one another and dedifferentiate, disassembling their sarcomeric structure in the process. In situ and microarray analysis indicate that dynamic changes in gene expression are also associated with heart regeneration. At present only handful of genes have been directly linked to heart regeneration in zebrafish. Our main objective is to expand this small list and thus provide candidates which can subsequently be manipulated in mammals. To determine suitable target genes, we will make use of the substantial microarray data generated from studying heart regeneration in zebrafish. Importantly, this data has revealed that certain genes shown to be up-regulated during zebrafish heart regeneration have previously been shown to positively regulate cardiomyocyte proliferation in mammalian models. These findings not only indicate that zebrafish and mammals share similar genetic mechanisms as far as regulating cardiomyocyte proliferation but also verify that the data represented in the microarrays contains positive candidate genes. Once candidates have been selected and confirmed in our zebrafish model system, we will begin testing these in vitro in mammalian cardiomyocytes before creating transgenic mouse models to determine whether they are capable of inducing myocardial regeneration following cardiac ischemia.'

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