EVOTHYME

Thymopoiesis: From Evolutionary Origins to Future Therapies

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 2˙496˙900 €
 EC contributo 2˙496˙900 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-ADG_20120314
 Funding Scheme ERC-AG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-06-01   -   2018-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Thomas
Cognome: Boehm
Email: send email
Telefono: +49 761 5108328
Fax: +49 761 5108220

DE (MUENCHEN) hostInstitution 2˙496˙900.00
2    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Martina
Cognome: Enderlein
Email: send email
Telefono: +49 761 5108 341
Fax: +49 761 5108 220

DE (MUENCHEN) hostInstitution 2˙496˙900.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

differentiation    intrathymic    thymic    informed    fish    additionally    genetic    animal    haematopoietic    thymopoiesis    function    genes    cells    thymopoietic    epithelial    networks    cell    thymus    evolutionarily   

 Obiettivo del progetto (Objective)

'The role of the thymus in cell-mediated immunity was discovered about 50 years ago and it has since become apparent that the thymus is the site of T cell development in all extant vertebrates. Although it has been recognized that thymopoiesis can only be fully understood by the analysis of both the thymic epithelial microenvironment and the intrathymic haematopoietic compartment, significant gaps in our knowledge of thymopoiesis remain. The proposal addresses major biological questions of thymopoiesis in a novel way. It is based on an evolutionarily informed approach that makes iterative use of distinct animal models (fish and mouse), and additionally considers information obtained from the analysis of human patients with thymopoietic deficiencies. The proposal aims to develop an animal model conducive to transplantation of xenogeneic haematopoietic progenitor cells. This system will be used for subsequent analysis of haematopoietic and immunological properties of genetically intractable fish species. The proposal also aims to determine the structure of genetic networks underlying the development and function of thymic epithelial cells and intrathymic T cell differentiation. This information will be used to explore the possibility of alleviating the phenotypic consequences of disease genes by interfering with the function of genes situated elsewhere in the respective genetic networks rather than by restoring faulty gene function. Evolutionarily constrained inventories of such genetic networks will be additionally used for the design of synthetic thymopoietic environments in non-cognate tissues, either using combinations of thymopoietic factors or by exploiting the thymopoietic capacity of Foxn1, a master regulator of thymic epithelial cell differentiation. Overall, the proposal aims at the development of evolutionarily informed genetic and cell-based strategies to reverse failing thymus function.'

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METABASE (2014)

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