PEPTIDE DIVERSITY

Diversity of MHC/peptide complexes in thymic compartments and their role in shaping T cell repertoire

 Coordinatore LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Ludger
Cognome: Klein
Email: send email
Telefono: +49 89 218075696
Fax: +49 89 51602236

 Nazionalità Coordinatore Germany [DE]
 Totale costo 161˙968 €
 EC contributo 161˙968 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-06-01   -   2015-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Ludger
Cognome: Klein
Email: send email
Telefono: +49 89 218075696
Fax: +49 89 51602236

DE (MUENCHEN) coordinator 161˙968.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

self    complexes    peptide    cells    us    autoimmunity    functional    related    mhc    mediate    disorders    technologies    antigen    immune    repertoire    cell   

 Obiettivo del progetto (Objective)

'Impaired selection of a functional and self-tolerant T cell repertoire is an underlying cause for development of immune system related disorders: immune-deficiencies and autoimmunity. However, current knowledge fails to explain how seemingly the same self-MHC/peptide complexes mediate the processes with completely different outcomes: survival versus apoptosis of T cells. In line, the nature of MHC/peptide complexes that mediate development of immune system and the influence of different antigen processing pathways on these complexes remain unresolved issues. The limitations of available technologies have left this question open. Recent advancement in the field of proteomics allows us now to precisely identify naturally occurring peptides that mediate selection of T cells. In addition, gene replacement technologies will be used to address the role of cathepsins, antigen-processing enzymes, on development of a fully functional T cell repertoire on one hand, and their effect on the quality and/or quantity of peptide epitopes displayed by cells that mediate T cell selection, on the other. The integration of proteomic methodology with in vivo experimental approach will enable us for the first time to interconnect the knowledge gained on cellular processes with direct physiological consequences in live animals. These new insights can accelerate not only discoveries related to T cell development, but are also relevant for understanding the interplay between T cells and pathogens, and can pave the way for new design and development of vaccines against infection diseases and therapies to treat autoimmunity. Thus, it directly contributes to strengthening European excellence in biomedical research. The host laboratory is one of the leading laboratories in the field of T cell biology that provides necessary expertise for successful realization of proposed project and the fellow has an outstanding track record of addressing questions related to immune-system related disorders.'

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