NANORADAM

Probing DNA Radiation Damage by DNA Nanotechnology

 Coordinatore UNIVERSITAET POTSDAM 

 Organization address address: AM NEUEN PALAIS 10
city: POTSDAM
postcode: 14469

contact info
Titolo: Dr.
Nome: Regina
Cognome: Gerber
Email: send email
Telefono: +49 331 977 1080
Fax: +49 331 977 1298

 Nazionalità Coordinatore Germany [DE]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-04-01   -   2017-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET POTSDAM

 Organization address address: AM NEUEN PALAIS 10
city: POTSDAM
postcode: 14469

contact info
Titolo: Dr.
Nome: Regina
Cognome: Gerber
Email: send email
Telefono: +49 331 977 1080
Fax: +49 331 977 1298

DE (POTSDAM) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

nucleotide    therapeutics    technique    radiation    electrons    fundamental    cancer    strand    break    origami    mechanisms    damage    therapy    sequences    energy    yield    structures    dna   

 Obiettivo del progetto (Objective)

'In cancer radiation therapy predetermined doses of high-energy radiation are administered to reduce tumours. More than 60 % of the patients diagnosed with cancer are treated with radiation therapy. A detailed understanding of the fundamental mechanisms of DNA radiation damage is of utmost importance with respect to the question of how the damage can be increased by therapeutics used in radiation therapy. On a molecular level a large extent of the cell damage is ascribed to the production of secondary low-energy electrons along the high-energy radiation track that induce DNA single and double strand breaks. The physico-chemical mechanisms of DNA radiation damage can currently only be described for idealized small model systems and it is not known, which DNA nucleotide sequences and higher-order DNA structures are most susceptible to damage. Very recent ground-breaking advances in DNA nanotechnology allow for the first time the detailed study of the interaction of radiation with complex DNA structures. With an innovative DNA origami technique it is possible to map the radiation damage of different DNA target structures with unprecedented efficiency and accuracy. A two-dimensional DNA origami template functionalized with protruding well-defined DNA structures will be exposed to a beam of low-energy electrons. The strand break yield of different nucleotide sequences will be determined as a function of the electron energy using the DNA origami technique combined with atomic force microscopy. Furthermore, the DNA origami technique allows for the study of the influence of an aqueous environment on the DNA strand break yield. The final goal is to identify the DNA target structures that can be most efficiently sensitized to low-energy electrons by radiosensitizers. This fundamental knowledge will have important implications for the development of novel therapeutics and the improvement of radiation cancer therapy.'

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