NONCODOWN

Optimizing Antisense Oligonucleotides for Efficient and Specific Knockdown of Nuclear Non-Coding RNA

Coordinatore	UNIVERSITY OF SOUTHAMPTON    more  Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ contact info Titolo: Ms. Nome: Yan Cognome: Qiao Email: send email Telefono: +44 2380 593907
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-06-01   -   2017-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF SOUTHAMPTON  Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ contact info Titolo: Ms. Nome: Yan Cognome: Qiao Email: send email Telefono: +44 2380 593907	UK (SOUTHAMPTON)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

The past decade has seen a dramatic increase in discovery of noncoding RNA with functional regulatory roles in the nucleus of mammalian cells. Yet tools to manipulate these nuclear noncoding RNAs remain inadequate. This proposal will develop optimized antisense oligonucleotides for targeting and degrading structured RNAs in the nucleus. This will be carried out by using both the best of what already exists in the field of nucleic acid chemistry (e.g. locked nucleic acid and the gapmer approach) and innovative new designs (e.g. CuAAC-derived PNA-DNA-LNA chimeric oligomers for degrading structured RNA targets).