"Understanding Halogenated Lipids: Synthesis, Mode of Action, Structural Studies, and Applications"


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 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 2˙233˙240 €
 EC contributo 2˙233˙240 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-ADG_20120216
 Funding Scheme ERC-AG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-03-01   -   2018-02-28


# participant  country  role  EC contrib. [€] 

 Organization address address: Raemistrasse 101
postcode: 8092

contact info
Titolo: Prof.
Nome: Erick Moran
Cognome: Carreira
Email: send email
Telefono: +41 44 632 28 30
Fax: +41 44 632 28 90

CH (ZUERICH) hostInstitution 2˙233˙240.00


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

discovery    structural    mechanism    examination    characterization    toxins    natural    biological    isolated    lipid   

 Obiettivo del progetto (Objective)

'Among the various toxins isolated, the chlorosulfolipids are particularly intriguing because of their structural and stereochemical complexity. The mechanism of biological activity remains unknown. The lack of availability of the natural products has impaired more in-depth studies aimed at pharmacological, biological, and chemical characterization for proper evaluation of the risk for human health and their role in nature. The proposal takes as its basis this unusual class of natural products and delineates a multifaceted program of inquiry involving: (1) structural characterization of the most complex chlorosulfolipid isolated to date, (2) conformational studies in solution of chlorinated lipids, (3) synthesis and study of brominated lipid analogs, (4) development of analytical methods for detection of these toxins in the environment, (5) the discovery and development of reagents and catalysts for asymmetric chlorination of olefins, (6) examination of lipid conformation in constrained media, (7) examination of the mechanism of anchimeric assistance by chlorides, and (8) applications to drug discovery.'

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