INNATE_CROSSTALK
Innate immunity crosstalk in immunoregulation
| Coordinatore | ISTITUTO GIANNINA GASLINI
Organization address
address: VIA GEROLAMO GASLINI 5 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 86˙868 € |
| EC contributo | 86˙868 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2007-2-1-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-07-01 - 2009-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ISTITUTO GIANNINA GASLINI
Organization address
address: VIA GEROLAMO GASLINI 5 contact info |
IT (GENOVA) | coordinator | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Innate immunity is believed to protect mammalians from most infections. In the majority of cases, the quick responses by innate effector cells clear the infection before adaptive immunity develops. In recent years it has become evident that the early crosstalk between different innate immune cells also has a role in the development of adaptive immunity. In particular, NK-dendritic cell (DC) interactions have been identified as key events in shaping the adaptive immune response. However, the role of other innate cells in these interactions has been less characterized. In this project, we will study the interaction of activated neutrophils with NK cells and the impact of neutrophils on the crosstalk between NK cells and DCs, which is of importance for the development of the ensuing adaptive immune response. We also aim to identify the ligands for the two innate immunity receptors, IRp60, which is expressed by NK cells and neutrophils, and NKp30, an activating NK cell receptor that is of importance in the NK-DC crosstalk. The identification of these ligands would enhance our understanding of the interactions occurring between these different innate immunity cell types.'
Introduzione (Teaser)
White blood cell interactions or crosstalk may help reveal how immune reactions and inflammation work, leading to better understanding of the immune system.