ENANTIOMEAR

Enantioselective Metal Enolate Alkylation Reactions Under Cooperative Lewis Base and Hydrogen-bond Donor

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	221˙606 €
EC contributo	221˙606 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IEF
Funding Scheme	MC-IEF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-04-15   -   2015-04-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	221˙606.40

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 Obiettivo del progetto (Objective)

'The reaction between a metal enolate ion and an alkyl halide (or equivalent) electrophile is one of the most useful process for the formation of carbon-carbon bond in organic synthesis. We wish to develop enantioselective metal enolate alkylation reactions under cooperative Lewis base and Hydrogen-bond donor catalysis. The combination of Lewis basic H-bond donor and metal enolate ion to interact cooperatively to both activate and organise the enolate towards the electrophilic component, be it alkyl halide, Michael acceptor or anything else. During this Fellowship we wish to investigate this concept fully with the intention of discovering a new way of generating asymmetry in enolate alkylation reactions through the action of a chiral controller. Not only will these reactions constitute important developments in the field but the product structures are often biologically relevant, thus lending the chemistry to important synthetic applications. Accordingly the design and implementation of a new and broadly applicable methodology to solve the enantioselectivecatalytic alkylation reaction would have a significant impact on organic synthesis and is the focus of this proposal.'