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TAILORED-TREATMENT

DEVELOPMENT OF TAILORED ANTIMICROBIAL TREATMENT REGIMENS AND NOVEL HOST- PATHOGEN INSIGHTS FOR RESPIRATORY TRACT INFECTIONS AND SEPSIS

Coordinatore	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Dr. Nome: John Cognome: Hays Email: send email Telefono: +31 107032177 Fax: +31 107033875
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	7˙767˙671 €
EC contributo	5˙975˙383 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-08-01 - 2017-07-31

Partecipanti

#	participant	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: 's Gravendijkwal 230 city: ROTTERDAM postcode: 3015CE contact info Titolo: Dr. Nome: John Cognome: Hays Email: send email Telefono: +31 107032177 Fax: +31 107033875	NL (ROTTERDAM)	coordinator	1˙438˙430.00
2	MEMED DIAGNOSTICS LTD Organization address address: NAHUM HETH STREET 5 city: TIRAT CARMEL postcode: 39120 contact info Titolo: Dr. Nome: Eran Cognome: Eden Email: send email Telefono: +972 48500302 Fax: +972 48500298	IL (TIRAT CARMEL)	participant	1˙512˙452.80
3	GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Ellen Cognome: Rydberg Email: send email Telefono: +46 31 786 6470 Fax: +46 31 786 4355	SE (GOETEBORG)	participant	1˙012˙720.00
4	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX contact info Titolo: Prof. Nome: Louis Cognome: Bont Email: send email Telefono: +31 887554001	NL (UTRECHT)	participant	729˙987.00
5	NORAY BIOINFORMATICS SL Organization address address: PARQUE TECNOLOGICO 801A city: DERIO postcode: 48160 contact info Titolo: Dr. Nome: Eva Cognome: González Email: send email Telefono: +34 944036998 Fax: +34 944036999	ES (DERIO)	participant	528˙411.80
6	HADASSAH MEDICAL ORGANIZATION Organization address address: n/a city: JERUSALEM postcode: 91120 contact info Titolo: Prof. Nome: Dan Cognome: Engelhard Email: send email Telefono: +972 26778960 Fax: +972 26434579	IL (JERUSALEM)	participant	496˙381.40
7	IBEXPERTS Ltd. Organization address address: HAALON STREET 16A city: RAANANA postcode: 43572 contact info Titolo: Dr. Nome: Racheli Cognome: Kreisberg Email: send email Telefono: 97297411769	IL (RAANANA)	participant	257˙000.00

Mappa

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Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

biomarkers patient broad dataset dimensional adults adverse data infections presenting clinical host sepsis emergence interactions algorithm children respiratory pathogen physicians patients tools personalized antibiotic events predictive resistance treatment antimicrobial antibiotics

Obiettivo del progetto (Objective)

'Though of tremendous benefit, the overuse of antibiotics has lead to the emergence of antibiotic resistance and may cause adverse events that impact on patient healthcare. Current diagnostic tools for facilitating the appropriate use of antibiotics in patients are inadequate.

We will establish a broad-based strategy (not limited to a particular antibiotic group) that can be implemented on a broad scale to increase the effectiveness of antimicrobial therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in children and adults.

At the heart of the TAILORED-Treatment project is a prospective clinical study in which we will recruit 1200 patients (>2000 patient samples) presenting with respiratory tract infections and/or sepsis. Patient cohorts will include equal representation of genders, children and adults. State-of-the-art molecular technologies will be applied to characterize host-pathogen interactions at the genomic, transcriptomic, proteomic and clinical level, resulting in a large-scale and unique multi-dimensional dataset. The consortium partners will develop new computational tools to interrogate this data, in order to provide new insights into personalized host-pathogen interactions, including the discovery of novel biomarkers for physicians to use in patient diagnosis and disease monitoring.

Concurrently, using this data, we will construct a predictive personalized treatment algorithm that will lead to informed and personalized antimicrobial treatment regimens (indication, dosage, and duration) that are tailored to the needs (type of infection, presence of novel biomarkers etc) of children and adults presenting with respiratory infections and sepsis.

This unique multi-dimensional dataset and personalized predictive treatment algorithm will be built into an easily navigable web-based, free-to-use, decision support system for use by physicians to explore and assist in patient-tailored antimicrobial treatment decisions.'