TAILORED-TREATMENT

DEVELOPMENT OF TAILORED ANTIMICROBIAL TREATMENT REGIMENS AND NOVEL HOST- PATHOGEN INSIGHTS FOR RESPIRATORY TRACT INFECTIONS AND SEPSIS

 Coordinatore ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Dr.
Nome: John
Cognome: Hays
Email: send email
Telefono: +31 107032177
Fax: +31 107033875

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 7˙767˙671 €
 EC contributo 5˙975˙383 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-08-01   -   2017-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Dr.
Nome: John
Cognome: Hays
Email: send email
Telefono: +31 107032177
Fax: +31 107033875

NL (ROTTERDAM) coordinator 1˙438˙430.00
2    MEMED DIAGNOSTICS LTD

 Organization address address: NAHUM HETH STREET 5
city: TIRAT CARMEL
postcode: 39120

contact info
Titolo: Dr.
Nome: Eran
Cognome: Eden
Email: send email
Telefono: +972 48500302
Fax: +972 48500298

IL (TIRAT CARMEL) participant 1˙512˙452.80
3    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Dr.
Nome: Ellen
Cognome: Rydberg
Email: send email
Telefono: +46 31 786 6470
Fax: +46 31 786 4355

SE (GOETEBORG) participant 1˙012˙720.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Prof.
Nome: Louis
Cognome: Bont
Email: send email
Telefono: +31 887554001

NL (UTRECHT) participant 729˙987.00
5    NORAY BIOINFORMATICS SL

 Organization address address: PARQUE TECNOLOGICO 801A
city: DERIO
postcode: 48160

contact info
Titolo: Dr.
Nome: Eva
Cognome: González
Email: send email
Telefono: +34 944036998
Fax: +34 944036999

ES (DERIO) participant 528˙411.80
6    HADASSAH MEDICAL ORGANIZATION

 Organization address address: n/a
city: JERUSALEM
postcode: 91120

contact info
Titolo: Prof.
Nome: Dan
Cognome: Engelhard
Email: send email
Telefono: +972 26778960
Fax: +972 26434579

IL (JERUSALEM) participant 496˙381.40
7    IBEXPERTS Ltd.

 Organization address address: HAALON STREET 16A
city: RAANANA
postcode: 43572

contact info
Titolo: Dr.
Nome: Racheli
Cognome: Kreisberg
Email: send email
Telefono: 97297411769

IL (RAANANA) participant 257˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

events    dataset    respiratory    algorithm    tools    sepsis    presenting    pathogen    adverse    antimicrobial    clinical    patients    interactions    resistance    broad    antibiotic    patient    data    adults    dimensional    infections    predictive    emergence    children    personalized    physicians    biomarkers    antibiotics    host    treatment   

 Obiettivo del progetto (Objective)

'Though of tremendous benefit, the overuse of antibiotics has lead to the emergence of antibiotic resistance and may cause adverse events that impact on patient healthcare. Current diagnostic tools for facilitating the appropriate use of antibiotics in patients are inadequate.

We will establish a broad-based strategy (not limited to a particular antibiotic group) that can be implemented on a broad scale to increase the effectiveness of antimicrobial therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in children and adults.

At the heart of the TAILORED-Treatment project is a prospective clinical study in which we will recruit 1200 patients (>2000 patient samples) presenting with respiratory tract infections and/or sepsis. Patient cohorts will include equal representation of genders, children and adults. State-of-the-art molecular technologies will be applied to characterize host-pathogen interactions at the genomic, transcriptomic, proteomic and clinical level, resulting in a large-scale and unique multi-dimensional dataset. The consortium partners will develop new computational tools to interrogate this data, in order to provide new insights into personalized host-pathogen interactions, including the discovery of novel biomarkers for physicians to use in patient diagnosis and disease monitoring.

Concurrently, using this data, we will construct a predictive personalized treatment algorithm that will lead to informed and personalized antimicrobial treatment regimens (indication, dosage, and duration) that are tailored to the needs (type of infection, presence of novel biomarkers etc) of children and adults presenting with respiratory infections and sepsis.

This unique multi-dimensional dataset and personalized predictive treatment algorithm will be built into an easily navigable web-based, free-to-use, decision support system for use by physicians to explore and assist in patient-tailored antimicrobial treatment decisions.'

Altri progetti dello stesso programma (FP7-HEALTH)

NEUROPRO (2008)

OLIGOPEPTIDASE INHIBITORS IN BRAIN FUNCTION AND DYSFUNCTION: TOWARDS NEW THERAPEUTIC STRATEGIES FOR NEUROPROTECTION

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AIPGENE (2011)

Augmenting PBGD expression in the liver as a Novel Gene therapy for Acute Intermittent Porphyria

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RD-CONNECT (2012)

"RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research"

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