CLOCK DEVELOPMENT

Circadian Developmental Requirements

 Coordinatore  

 Organization address address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ

contact info
Titolo: Ms.
Nome: Yan
Cognome: Qiao
Email: send email
Telefono: +4423 8059 3907
Fax: +4423 8059 2195

 Nazionalità Coordinatore Non specificata
 Totale costo 100˙000 €
 EC contributo 10˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-01   -   2018-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF SOUTHAMPTON

 Organization address address: Highfield
city: SOUTHAMPTON
postcode: SO17 1BJ

contact info
Titolo: Ms.
Nome: Yan
Cognome: Qiao
Email: send email
Telefono: +4423 8059 3907
Fax: +4423 8059 2195

UK (SOUTHAMPTON) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

clk    phenotypes    functional    daily    circadian    bmal    neurons    human    cyc    genes    fruit    clocks    mechanisms    developmental    adult    clock    flies   

 Obiettivo del progetto (Objective)

'Circadian clocks are internal daily time keeping mechanisms that are required for autonomous daily rhythms in physiology and behaviour of both fruit flies and humans. Our previous work has identified a developmental role in fruit flies for the transcription factor CLOCK/CYCLE (CLK/CYC), which represents a phylogenetic and functional orthologue of the key human circadian regulator CLOCK/BMAL1. By conditionally manipulating the developmental expression of the genes for CYC as well as the CLK/CYC inhibitor PERIOD (PER), we found that CLK/CYC acts in the clock neurons during metamorphosis to ensure that the adult neural clock circuit maintains the ability to generate circadian locomotor behaviour in constant darkness. The proposed research aims to elucidate this novel role for CLK/CYC by (1) more precisely identifying its spatiotemporal context, (2) determining the associated molecular and cellular phenotypes in adult clock neurons, and (3) systematically testing a number of candidate genes for their involvement in generating the observed phenotypes. Our experimental strategy takes advantage of a combination of fruit fly genetics, confocal immunofluorescence, and behavioural assays that are all well-established in our research group. Ultimately, elucidation of the signalling pathways connecting developmental CLK/CYC activity to overt circadian behaviour in adult flies will provide a compelling rationale for exploring analogous mechanisms associated with the homologous mammalian CLOCK/BMAL and NPAS2/BMAL complexes. Given the association of the Clock and Bmal genes with circadian control of a broad array of physiological functions including metabolism and sleep and the high degree of structural and functional conservation between the clocks of flies and human this study has strong relevance to human health and well-being.'

Altri progetti dello stesso programma (FP7-PEOPLE)

GOVMNC (2009)

"A longitudinal multilevel investigation of the influence of top management team, board of directors and CEO characteristics on firm strategy and performance of European MNCs"

Read More  

CTA-VLC COMPARISON (2014)

Catania and Valencia’s way to modernity. A multidisciplinary comparison between two port cities within Mediterranean Europe (1850-1915)

Read More  

SOLSPANET (2011)

Solar and Space Weather Network of Excellence

Read More