TRANSPORET

Transmembrane Molecular Machines

 Coordinatore THE UNIVERSITY OF EDINBURGH 

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 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 1˙499˙780 €
 EC contributo 1˙499˙780 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-09-01   -   2018-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Elke
Cognome: Lammertyn
Email: send email
Telefono: +32 16 32 06 21

BE (LEUVEN) beneficiary 30˙000.00
2    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Dr.
Nome: Scott
Cognome: Cockroft
Email: send email
Telefono: +44 131 650 4758
Fax: +44 131 650 6453

UK (EDINBURGH) hostInstitution 1˙469˙780.00
3    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 650 9024
Fax: +44 131 651 9024

UK (EDINBURGH) hostInstitution 1˙469˙780.00

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 Word cloud

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project    molecular    logic    single    operate    molecule    chemical    machines    rotary    transmembrane    nanomechanical    biological   

 Obiettivo del progetto (Objective)

'This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical devices such as molecular rotors, walkers and logic devices, no such systems have been developed that operate across lipid membranes.

Thus, by exploiting our knowledge of biological and synthetic supramolecular components we seek to construct some of the first ever transmembrane molecular machines built to man-made specifications. Mirroring the operation of biological transmembrane molecular machines, compartmentalisation facilitates the construction of nanomechanical devices that can be driven by electrochemical gradients, or those that operate in the reverse sense by turning over chemical fuels to establish non-equilibrium conditions. We intend to demonstrate these principles by combining nanopore-based techniques and DNA-recognition processes to assemble a range of membrane-spanning nanomechanical devices that can be operated, controlled and monitored down to single-molecule levels:

Project 1 – Transmembrane logic & signalling on the single-molecule level. Project 2 – A transmembrane transporter. Project 3 – A transmembrane reciprocating pump. Project 4 – A transmembrane rotary motor.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

HIPECMEM (2011)

Memory-Related Information Processing in Neuronal Circuits of the Hippocampus and Entorhinal Cortex

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TEMS (2013)

The Effects of Marketization on Societies: The Case of Europe

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OVERHEATING (2012)

The three crises of globalisation: An anthropological history of the early 21st century

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