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SPELITEC SIGNED

Sequence sPecific ELImination of shiga-Toxin E. Coli

Total Cost €

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EC-Contrib. €

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Partnership

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 SPELITEC project word cloud

Explore the words cloud of the SPELITEC project. It provides you a very rough idea of what is the project "SPELITEC" about.

multinational    stecs    acquisition       resistance    eliminates    indication    orphan    companies    animals    model    designed    antibodies    validation    toxins    populations    children    strains    background    drug    bacteria    bacterial    business    safe    fatal    shiga    release    producing    clinically    transfusions    unmet    stec    clinical    progression    preclinical    complications    patients    liquid    first    eb003    solid    microbiota    consisting    plans    tests    market    exert    license    safety    conducting    spelitec    gel    coli    batch    pharmacological    therapeutic    disrupting    toxicity    disease    company    receive    authorization    complete    humans    initiate    rehydration    empts    alternative    infections    eligo    mechanism    selectively    elimination    multivalent    spectrum    finalise    toxin    receptors    action    primary    antibiotic    nature    healthy    inducing    treatments    pharma    hospitalized    mutation    dialysis    uremic    treatment    orally    mix    capsid    compound    paediatric    symptomatic    medical    validated    individualised    validate    launch    young    coupled    patient    variants    haemolytic    administered    team   

Project "SPELITEC" data sheet

The following table provides information about the project.

Coordinator
ELIGO BIOSCIENCE 

Organization address
address: 29 RUE FAUBOURG SAINT JACQUES PEPIN
city: PARIS
postcode: 75014
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙948˙250 €
 EC max contribution 2˙763˙775 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-2
 Funding Scheme SME-2
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELIGO BIOSCIENCE FR (PARIS) coordinator 2˙763˙775.00

Map

 Project objective

SPELITEC is the first treatment for Shiga toxin-producing E. coli (STEC) infections, which affects primary young children and can be fatal in 1-5% of the cases. Currently there is no validated safe treatment: hospitalized patients receive only symptomatic treatments consisting of rehydration coupled with transfusions and dialysis for haemolytic uremic complications. The SPELITEC program is designed to finalise preclinical and initiate clinical studies for elimination of STEC bacteria (Shiga-toxin producing E. coli) in paediatric populations with a dedicated product: EB003. EB003 selectively eliminates STEC bacteria early in the disease progression; it is not expected to exert any toxicity in humans or animals; it is a multivalent mix of different capsid variants allows to target the whole spectrum of clinically relevant strains and pre-empts the acquisition of resistance through mutation of bacterial receptors; it is administered orally by a liquid/gel which is patient-friendly and adapted to young children and it represents a cost-effective alternative to antibodies against Shiga toxins. Our technology is the only one allowing the specific elimination of STECs without toxin release and without disrupting microbiota and inducing antibiotic resistance. Eligo will complete early drug development, which should ensure market authorization given the orphan and unmet medical need nature of the indication, and plans to out-license the compound to an established pharma company that will launch the product on the market. The management team of Eligo has solid business and technical management experience in multinational companies and a very strong drug development background. During the Phase 2 project we will validate this new individualised therapeutic approach and mechanism of action by conducting the validation of the pharmacological model, the production of a clinical batch and the safety tests in healthy animals.

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The information about "SPELITEC" are provided by the European Opendata Portal: CORDIS opendata.

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