THYMISTEM

Development of Stem Cell Based Therapy for Thymic Regeneration

 Coordinatore THE UNIVERSITY OF EDINBURGH 

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 1316509024

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 7˙748˙982 €
 EC contributo 5˙996˙455 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 1316509024

UK (EDINBURGH) coordinator 1˙838˙061.00
2    NANOPHARMA AS

 Organization address address: NOVA 306
city: PARDUBICE
postcode: 530 09

contact info
Titolo: Ms.
Nome: Katerina
Cognome: Lajblova
Email: send email
Telefono: 420731000000

CZ (PARDUBICE) participant 899˙472.94
3    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Ms.
Nome: María ángeles
Cognome: López Váquez
Email: send email
Telefono: +34 915681462
Fax: +34 915681573

ES (MADRID) participant 750˙000.00
4    Sloan-Kettering Institute for Cancer Research CORPORATION

 Organization address address: York Avenue 1275
city: New York
postcode: 10065

contact info
Titolo: Mr.
Nome: Mark
Cognome: Svenningson
Email: send email
Telefono: 16462273414
Fax: 12126398207

US (New York) participant 749˙999.75
5    OPEN INTERNATIONAL UNIVERSITY OF HUMAN DEVELOPMENT UKRAINE

 Organization address address: Khoryva 1-G
city: Kyiv
postcode: 4071

contact info
Titolo: Prof.
Nome: Valentin
Cognome: Shichkin
Email: send email
Telefono: +38 097 5072932

UA (Kyiv) participant 720˙000.20
6    YEDITEPE UNIVERSITY

 Organization address address: Agustos Yerlesimi Kayisdagi Cad. 26
city: Istanbul
postcode: 34755

contact info
Titolo: Ms.
Nome: Ozge
Cognome: Kaya
Email: send email
Telefono: +90 2165780748
Fax: 902166000000

TR (Istanbul) participant 538˙400.00
7    RUDER BOSKOVIC INSTITUTE

 Organization address address: Bijenicka cesta 54
city: ZAGREB
postcode: 10000

contact info
Titolo: Ms.
Nome: Marijana
Cognome: Klasnic Kozar
Email: send email
Telefono: +385 14571342
Fax: 38514680250

HR (ZAGREB) participant 500˙521.60

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

optimized    reconstitution    human    function    stem    patients    immune    tesc    cryopreservation    thymus    epithelial    immunocompromised    thymic    cells    cell    protocols    tissue    transplantation   

 Obiettivo del progetto (Objective)

'Reconstitution of immune system function in immunocompromised patients depends on the presence of a functional thymus, and specifically, on the diverse array of epithelial cells within the thymic stroma. The thymus is the first organ to degenerate in normal healthy individuals, and is also sensitive to cytotoxic interventions. Therefore lack of thymic function presents a serious problem for many patients. Transplantation of neonatal human thymus can lead to successful immune system reconstitution, but limited tissue supply prevents its widespread use. Thymic epithelial stem cells (TESC), which can generate all of the epithelial subpopulations of the adult thymus, present an alternative source of transplantable cells. However, protocols for growing or generating TESC in the laboratory have not yet been developed. This proposal aims to develop robust and scalable protocols for the long-term in vitro culture of functionally validated human TESC, including standardized quality controls, and to establish optimized means of delivering these cells to immunocompromised recipients such that thymus function is fully restored. It also aims to develop optimized procedures for cryopreservation of human thymic stromal cells. These objectives relate directly to the topic identified in call HEALTH.2013.1.4-1 Controlling differentiation and proliferation in human stem cells intended for therapeutic use. THYMISTEM brings together a strong, pan-European team comprising thymus and stem cell biologists, immunologists working in humanized mouse models, haematologists expert in immune reconstitution, tissue engineers, and experts in cryopreservation and cell banking, to deliver these goals. Overall, this work will build the preclinical foundations required for development of a novel stem-cell based therapy: transplantation of thymic epithelial stem cell-based organoids for regenerative recovery of thymic - and thus immune system - function in patients.'

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