HERACLES

Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies

 Coordinatore ISTITUTO SUPERIORE DI SANITA 

 Organization address address: Viale Regina Elena 299
city: ROMA
postcode: 161

contact info
Titolo: Dr.
Nome: Rosa
Cognome: Martoccia
Email: send email
Telefono: +39 06 4990 2688
Fax: +39 06 4990 3007

 Nazionalità Coordinatore Italy [IT]
 Totale costo 3˙784˙916 €
 EC contributo 2˙861˙500 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ISTITUTO SUPERIORE DI SANITA

 Organization address address: Viale Regina Elena 299
city: ROMA
postcode: 161

contact info
Titolo: Dr.
Nome: Rosa
Cognome: Martoccia
Email: send email
Telefono: +39 06 4990 2688
Fax: +39 06 4990 3007

IT (ROMA) coordinator 693˙168.00
2    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Ms.
Nome: María ángeles
Cognome: López Vázquez
Email: send email
Telefono: +34 915681462
Fax: +34 915681573

ES (MADRID) participant 473˙092.00
3    UNIVERSITA DEGLI STUDI DI PAVIA

 Organization address address: STRADA NUOVA 65
city: PAVIA
postcode: 27100

contact info
Titolo: Dr.
Nome: Sofia
Cognome: Baggini
Email: send email
Telefono: +39 0382 984227
Fax: +39 0382 986906

IT (PAVIA) participant 450˙270.00
4    HACETTEPE UNIVERSITESI

 Organization address address: HACETTEPE UNIVERSITESI BEYTEPE KAMPUSU REKTORLUK BINASI
city: CANKAYA ANKARA
postcode: 6800

contact info
Titolo: Dr.
Nome: Serpil Sevtap
Cognome: Benli
Email: send email
Telefono: +90 312 3052191
Fax: +90 312 3117906

TR (CANKAYA ANKARA) participant 350˙000.00
5    SPITATUL CLINIC COLENTINA BUCURESTI

 Organization address address: SOSEAUA STEFAN CEL MARE 19-21
city: BUCURESTI
postcode: 20125

contact info
Titolo: Dr.
Nome: Maria
Cognome: Dinescu
Email: send email
Telefono: +4021 317 3245
Fax: +40 316 5512

RO (BUCURESTI) participant 350˙000.00
6    "SPECIALIZED HOSPITAL FOR ACTIVE TREATMENT OF INFECTIOUS AND PARASITIC DISEASES ""PROF. I. KIROV'"

 Organization address address: ACAD. IVAN GESHOV BLVD 17
city: SOFIA
postcode: 1606

contact info
Titolo: Prof.
Nome: Kamenna Marinova
Cognome: Vutova
Email: send email
Telefono: 35929523780
Fax: 35929520101

BG (SOFIA) participant 200˙000.00
7    NAMIK KEMAL UNIVERSITESI*NAMIK KEMAL UNIVERSITY NKU

 Organization address address: NAMIK KEMAL UNIVERSITY CAMPUS
city: Tekirda?
postcode: 59030

contact info
Titolo: Mr.
Nome: Mustafa
Cognome: Durgut
Email: send email
Telefono: +90 282 250 1511
Fax: +90 282 250 99 08

TR (Tekirda?) participant 125˙000.00
8    VIRCELL SL

 Organization address address: P.I DOS DE OCTUBRE PZA DOMINGUEZ ORTIZ 1
city: SANTA FE GRANADA
postcode: 18320

contact info
Titolo: Dr.
Nome: Arantxa
Cognome: Cortés
Email: send email
Telefono: +34 958 441264
Fax: +34 958 510712

ES (SANTA FE GRANADA) participant 119˙970.00
9    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU

 Organization address address: VIA FIORENTINA 151
city: SIENA
postcode: 53100

contact info
Titolo: Dr.
Nome: Cristiana
Cognome: Tozzi
Email: send email
Telefono: +39 0577 587906

IT (SIENA) participant 100˙000.00
10    MINISTRY OF FOOD AGRICULTURE AND LIVESTOCK

 Organization address address: Eski?ehir Yolu 9. Km
city: Ankara
postcode: 6060

contact info
Titolo: Dr.
Nome: Alparslan
Cognome: Temucin
Email: send email
Telefono: +90 2163901280
Fax: 902164000000

TR (Ankara) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

parasite    care    treatment    drug    abz    disease    endemic    countries    cee    ce    rural    human    chronic    health    diagnosis    clinical    surveillance   

 Obiettivo del progetto (Objective)

'Human cystic echinococcosis (CE), one of the most widespread helminthic zoonoses, is a chronic disease caused by infection with the larval stage of the tapeworm Echinococcus granulosus. This disease is highly endemic in some southern (Spain and Italy), eastern (Bulgaria and Romania) European countries and associated (Turkey) countries, where it still represents a major health and economic problem. In endemic areas the annual incidence of CE ranges from 1 to 200 per 100,000 inhabitants and 2-3 million cases are globally estimated. Case series and small clinical trials show a mortality rate of 2-4% for CE, but this increases markedly with substandard treatment and care. The diagnosis of human CE is mainly based on imaging techniques and serological confirmation. Clinical decision making is difficult and the natural history of the cyst is still poorly known. CE is chronic, complex and still neglected. For these reasons the main objectives of HERACLES are:

• Identify by ultrasound screening the population affected by CE in endemic rural areas of CEE countries; • Create CEE national registries for surveillance of CE; • Establish a representative bio-bank of genetic Egc isolates and blood/serum/plasma samples; • Validate new molecular-based POC-LOC kits for immunological surveillance, diagnosis and follow-up; • Identify factor/s associated with CE response to therapy or lack thereof through investigation of host-parasite interplay (parasite virulence vs human immunity); • Increase drug bioavailability in an in vivo model, decreasing the length of antiparasitic (ABZ based) treatment of CE and synthesize a new enantiomeric drug based on ABZ.

The project stakeholders, especially the rural populations in which CE is endemic, as well as SMEs, will be engaged as an integral part of the project. Special events to increase general awareness of CE and training activities for local health care providers will be organized.'

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