PLOIDYNET

The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy

 Coordinatore STICHTING HET NEDERLANDS KANKER INSTITUUT 

 Organization address address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX

contact info
Titolo: Dr.
Nome: Henri
Cognome: Van Luenen
Email: send email
Telefono: +3120 5122097

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 3˙017˙790 €
 EC contributo 3˙017˙790 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT

 Organization address address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX

contact info
Titolo: Dr.
Nome: Henri
Cognome: Van Luenen
Email: send email
Telefono: +3120 5122097

NL (AMSTERDAM) coordinator 329˙920.20
2    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Dr.
Nome: Floris
Cognome: Foijer
Email: send email
Telefono: +31 622800168

NL (GRONINGEN) participant 376˙758.38
3    CANCER RESEARCH UK

 Organization address address: ST JOHN STREET 407 ANGEL BUILDING
city: LONDON
postcode: EC1V 4AD

contact info
Titolo: Ms.
Nome: Holly
Cognome: Elphinstone
Email: send email
Telefono: +44 2072693524
Fax: 442073000000

UK (LONDON) participant 296˙056.62
4    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 650 9024
Fax: +44 131 651 4028

UK (EDINBURGH) participant 296˙056.62
5    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Ms.
Nome: Claire
Cognome: Faichnie
Email: send email
Telefono: +44 161 2755449

UK (MANCHESTER) participant 296˙056.62
6    UNIVERSITAET BASEL

 Organization address address: Petersplatz 1
city: BASEL
postcode: 4003

contact info
Titolo: Prof.
Nome: Erich
Cognome: Nigg
Email: send email
Telefono: +4161 2671656

CH (BASEL) participant 272˙515.75
7    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Dr.
Nome: Sotillo
Cognome: Rocio
Email: send email
Telefono: +49 62213878316

DE (HEIDELBERG) participant 251˙837.95
8    UNIVERSITAIR MEDISCH CENTRUM UTRECHT

 Organization address address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX

contact info
Titolo: Prof.
Nome: Geert
Cognome: Kops
Email: send email
Telefono: +3188 7555163

NL (UTRECHT) participant 247˙861.45
9    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mrs.
Nome: Ulrike
Cognome: Jendis
Email: send email
Telefono: +49 89 8578 3853

DE (MUENCHEN) participant 233˙068.88
10    NETHERLANDS TRANSLATIONAL RESEARCH CENTER BV

 Organization address address: MOLENSTRAAT 110
city: OSS
postcode: 5342 CC

contact info
Titolo: Dr.
Nome: Guido
Cognome: Zaman
Email: send email
Telefono: +3141 2764071

NL (OSS) participant 215˙856.73
11    MILTENYI BIOTEC GMBH

 Organization address address: FRIEDRICH EBERT STRASSE 68
city: BERGISCH GLADBACH
postcode: 51429

contact info
Titolo: Dr.
Nome: Olaf Thorsten
Cognome: Hardt
Email: send email
Telefono: +49 220483064212

DE (BERGISCH GLADBACH) participant 201˙800.72

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

training    scientific    become    trainees    molecular    aneuploidy    vitro    labs    cells    cancer    network    chromosomes   

 Obiettivo del progetto (Objective)

'Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than stimulating proliferation. This suggests that cancer cells have acquired mutations that help them cope with aneuploidy. Although it is clear that aneuploidy can contribute to cancer, the molecular consequences of aneuploidy remain elusive, as does how aneuploidy contributes to malignant transformation. The scientific aim of this network is to determine and compare the molecular consequences of different levels of aneuploidy, both in vivo and in vitro. Our network will train 9 Early Stage Career and 2 Experienced researchers in the aneuploidy field. To this aim, we are combining the expertise of labs that study the causes of aneuploidy with labs that induce aneuploidy in model organisms and study its consequences and also with labs that focus on the development of therapeutics that selectively kill aneuploid cell progeny. Our network is comprised of 11 full participants in 4 member states and 1 associated country and one associated partner, and includes 3 commercial enterprises. Within this network, we will provide technical training through research projects, but also through workshops and dedicated courses organized by the participants of this network. A significant part of the training will be provided by the industrial partners. Participating investigators and trainees will meet at a yearly conference to exchange and discuss results. Trainees will thus become experts in the field of aneuploidy while rapidly building up a scientific network for themselves, putting them in an excellent position to become future leaders in this field.'

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