OXIDASPERM

Sexual Selection and the Evolution of Sperm Competitiveness: The Cost and the Avoidance of Oxidative Stress in Sperm Cells

Coordinatore	LIVERPOOL JOHN MOORES UNIVERSITY    more  Organization address address: Egerton Court Rodney Street 2 city: LIVERPOOL postcode: L3 5UX contact info Titolo: Mr. Nome: Ian Cognome: Pennington Email: send email Telefono: 441519000000
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-02-01   -   2017-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	LIVERPOOL JOHN MOORES UNIVERSITY  Organization address address: Egerton Court Rodney Street 2 city: LIVERPOOL postcode: L3 5UX contact info Titolo: Mr. Nome: Ian Cognome: Pennington Email: send email Telefono: 441519000000	UK (LIVERPOOL)	coordinator	50˙000.00
2	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: Ana María Cognome: De La Fuente Email: send email Telefono: +34 91 5681709	ES (MADRID)	participant	50˙000.00

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 Obiettivo del progetto (Objective)

'Sexual selection drives the rapid evolution of reproductive traits and genes. Specifically, high levels of sperm competition (the process in which female promiscuity forces the ejaculates from rival males to compete to fertilize the same ova) results in an improvement in sperm competitiveness. One of the main determinants of sperm competitiveness is swimming velocity, which enables sperm to outcompete rival sperm in the race to fertilize the ova. The increase in sperm metabolism associated with enhanced swimming speed is expected to increase levels of oxidative stress. Oxidative stress is known to affect sperm membranes as well as DNA integrity, leading to decreased sperm function and the transmission of genetic disease to offspring. We will investigate, in a group of closely related species of rodents that differ dramatically in their levels of sperm competition, if sperm competition results in higher levels of oxidative stress, and if such oxidative stress is prevented by the evolution of protective counter-measures such as changes in the composition of the plasma membrane, increased antioxidant defenses, or a greater degree of condensation of the DNA within the sperm head.'