PROBING-PAIN

Multimodal functional neuroimaging techniques to probe the representation of pain in the human brain

 Coordinatore UNIVERSITE CATHOLIQUE DE LOUVAIN 

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 Nazionalità Coordinatore Belgium [BE]
 Totale costo 1˙484˙333 €
 EC contributo 1˙484˙333 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-12-01   -   2018-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Mrs.
Nome: Anne
Cognome: Bovy
Email: send email
Telefono: 3210473873
Fax: 3210474830

BE (LOUVAIN LA NEUVE) hostInstitution 1˙484˙333.60
2    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Prof.
Nome: Andre Philippe J
Cognome: Mouraux
Email: send email
Telefono: 3227645447
Fax: 3227645465

BE (LOUVAIN LA NEUVE) hostInstitution 1˙484˙333.60

Mappa


 Word cloud

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cortical    stimuli    connectivity    experimental    human    sustained    perception    brain    pain    regions    humans    functional    noxious   

 Obiettivo del progetto (Objective)

'Pain may be defined as a primarily aversive perception that is vital for survival, as it incites the individual to respond to stimuli constituting a real or potential menace. However, pain is also a major healthcare issue, undermining the health and welfare of millions of individuals and imposing a severe financial burden to our societies. How does the brain process noxious stimuli, and how does this lead to the perception of pain? In humans, using functional neuroimaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI), a great number of studies have shown that noxious stimuli elicit activity within a widespread network of cortical regions, including the primary and secondary somatosensory cortices, the insula and the anterior cingulate cortex. However, recent studies have suggested that these responses are largely unspecific for pain and, instead, reflect attentional mechanisms that can be triggered by the occurrence of any salient sensory event, regardless of whether it elicits pain. Therefore, novel approaches are needed to progress in understanding the neural representation of pain in humans. This constitutes the main objective of this project in which we will develop a series of original experimental approaches to (1) explore how transient and sustained pain are respectively represented in the human brain, (2) characterize directly the functional connectivity, interdependency and hierarchical organization of the different brain regions involved in the perception of pain and (3) characterize the plastic changes in cortical excitability and functional connectivity induced by sustained experimental pain as well as chronic pathological pain. Each of these approaches has the potential to open a new line of research for basic and clinical pain neuroscience, with important development perspectives, such as the identification of novel human biomarkers for analgesic drug development and improved patient stratification.'

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