MYODYN

Myosins and the dynamics of intracellular membranes

 Coordinatore INSTITUT CURIE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore France [FR]
 Totale costo 2˙500˙000 €
 EC contributo 2˙500˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-ADG
 Funding Scheme ERC-AG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-02-01   -   2019-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Dr.
Nome: Bruno
Cognome: Goud
Email: send email
Telefono: +331 56 24 63 98
Fax: +331 56 24 64 21

FR (PARIS) hostInstitution 2˙500˙000.00
2    INSTITUT CURIE

 Organization address address: 26, rue d'Ulm
city: PARIS
postcode: 75248

contact info
Titolo: Mrs.
Nome: Corinne
Cognome: Cumin
Email: send email
Telefono: +331 56 24 66 20
Fax: +33 1 56 24 66 27

FR (PARIS) hostInstitution 2˙500˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

transport    cell    team       fission    dynamics    functioning    membrane    myosin    golgi    tgn    actin    myosins    motors    roles    microtubule    physical    deformation    goal    interface   

 Obiettivo del progetto (Objective)

'Myosins are fascinating proteins with unique biochemical and physical properties. The multiple roles that they play in the dynamics of intracellular membranes are only beginning to emerge. Recent findings from the research team have highlighted unexpected roles in membrane deformation and in membrane fission played by two myosins (myosin 1b and myosin II) functioning at the interface between the Golgi, TGN (Trans-Golgi Network) and endosomes. Building on these results, we propose to establish a comprehensive model describing how several myosins work in concert with F-actin and with microtubule-based motors for sustaining transport events and membrane dynamics in a region of the cell at the crossroads of complex trafficking pathways. Towards this general objective, our main goals are: Goal 1: to understand the role of myosin 1b in membrane deformation Goal 2: to understand the role of nonmuscle myosin II in membrane fission Goal 3: to characterize the actin structures required for myosin functions Goal 4: to identify and to characterize other myosins functioning at the Golgi/TGN/endosome interface and to investigate their functional coordination Goal 5: to understand how myosins are functionally coordinated with microtubule-based motors. The function of myosins will be studied both at the cellular and physical level using two main original methodological approaches available to the research team: minimal in vitro assays (giant liposomes and membrane nanotubes) and normalized cell systems (micropatterns). This proposal represents a new development in the activity of the research team composed of cell biologists, experimental and theoretical physicists. Success of this proposal will rely on the strong experience of cross-disciplinary approaches that allowed the research team in the past to elucidate several physical mechanisms underlying transport processes and membrane dynamics.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

VIRMUT (2012)

Variability in the mutation rate of RNA viruses

Read More  

GEMELLI (2010)

"Gene networks controlling embryonic polarity, regulation and twinning"

Read More  

HISKNOWL (2013)

Using Historical Quasi-Experiments to Understand the Knowledge Economy

Read More