MECHANODEVO
Mechanical signals in plants: from cellular mechanisms to growth coordination and patterning
| Coordinatore | INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 1˙869˙823 € |
| EC contributo | 1˙869˙823 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2013-CoG |
| Funding Scheme | ERC-CG |
| Anno di inizio | 2014 |
| Periodo (anno-mese-giorno) | 2014-06-01 - 2019-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Organization address
address: Rue De L'Universite 147 contact info |
FR (PARIS CEDEX 07) | hostInstitution | 1˙869˙823.00 |
| 2 |
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Organization address
address: Rue De L'Universite 147 contact info |
FR (PARIS CEDEX 07) | hostInstitution | 1˙869˙823.00 |
Mappa
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Obiettivo del progetto (Objective)
'Development relies on a complex network of molecular effectors that ultimately modify the mechanical properties of cells and control shape changes. In turn, mechanical forces can also feedback on the molecular network to govern development. Several mechanosensitive proteins have been identified in animals but their role in multicellular development remains poorly documented. Plants are ideal systems to study mechanotransduction in development because their mechanics is mainly mediated by the cell wall. Here we propose to identify the plant mechanotransduction pathways and investigate their role in development, using Arabidopsis cell culture, cotyledons and shoot apical meristems as experimental systems.
We will conduct a multiscale investigation into mechanotransduction, at the level of a cell, of a small group of cells, and of the tissue. We have already characterized the response of microtubules to mechanical stress using a set of micromechanical tools in these three systems, and we have identified a mechanosensing protein, which, when impaired, causes growth coordination defects in the epidermis and altered morphogenesis. We will identify and characterize other elements of the plant mechanotransduction pathways, including mechanosensitive genes and proteins, based on preliminary results and on a well-designed screen. Scaling up, we will generate transgenic lines in which patches of cells with altered mechanical properties can be induced, and we will test whether mechanical heterogeneities are used to coordinate cell wall remodeling and cell division in neighboring cells. Last, we will investigate whether these biophysical coordinating mechanisms contribute to patterning and cell fate in organs, focusing on the epidermis, the boundaries between expression domains, and stem cell identity. We will investigate whether mutants exhibiting identity defects can be rescued with applied mechanical forces or locally modified mechanical properties.'