SOX

The role of Sox2 in epithelial homeostasis and cancer

 Coordinatore UNIVERSITAET ZUERICH 

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Michael
Cognome: Hengartner
Email: send email
Telefono: +41 44 6353140

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 270˙964 €
 EC contributo 270˙964 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2015
 Periodo (anno-mese-giorno) 2015-04-01   -   2018-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET ZUERICH

 Organization address address: Raemistrasse 71
city: ZURICH
postcode: 8006

contact info
Titolo: Prof.
Nome: Michael
Cognome: Hengartner
Email: send email
Telefono: +41 44 6353140

CH (ZURICH) coordinator 270˙964.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    sox    tissue    mouse    stem    cancer    family    tumor    steps    genes   

 Obiettivo del progetto (Objective)

'The Sox family of transcription factors are versatile regulators of stem and progenitor cell fate. Sox2 is a well-characterized member of this family and plays essential roles during animal development and in adult stem cells. Accumulating evidence suggests that dysregulation of Sox2 expression is involved in key steps during tumorigenesis. However, the underlying molecular mechanisms of Sox2 in tumor formation and the Sox2 target genes mediating these phenotypes remain elusive. Here, using mouse skin as a model tissue, I propose to systematically profile the Sox2 regulatory network by RNA seq and ribosomal profiling. To determine the physiological relevance of Sox2 target gene changes, I plan to carry out an shRNA screen to uncover novel mediator of Sox2-dependent tissue growth. I will take advantage of the ultrasound-guided in utero microinjections of lentivirus into the amniotic cavity, which has been recently developed in our lab and allows to test the function of thousands of genes simultaneously. I will confirm and document the role of novel targets in mouse and human squamous cell carcinomas. Understanding how this stem cell regulator controls these key steps during tumor progression could be exploited not only for cancer diagnostics, but also in designing novel cancer therapies.'

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