FORMALBIO

Protein Synthesis Control by Means of Formal Models

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Renata
Cognome: Schaeffer
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 309˙235 €
 EC contributo 309˙235 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Ms.
Nome: Renata
Cognome: Schaeffer
Email: send email
Telefono: +44 1223 333543
Fax: +44 1223 332988

UK (CAMBRIDGE) coordinator 309˙235.20

Mappa

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

net    throughput    tools    petri    model    cellular    protein    biological    biology    recombinant    formal    intends    synthesis    optimize    mechanism   

 Obiettivo del progetto (Objective)

'Many biological systems at cellular level consist of a high number of elements interacting in complex patterns. These systems often exhibit emergent behaviours that cannot be detected by reductionist approaches. Systems biology is the interdisciplinary methodology aiming at understanding the dynamics of life by determining how the elements of a biological system interact to form functional networks. This research proposal intends to make to advance the state-of-the-art in systems biology by making systematic use of formal models, and more precisely of the Petri nets formalism. The research will focus on the network of interactions involved in the protein synthesis in Saccharomyces cerevisiae, a species of yeast. The overall goal of the proposal is to optimize the recombinant protein synthesis in this organism. This goal is to be achieved by means of three primary objectives: 1) to formally model the recombinant protein synthesis mechanism; 2) to analyse the obtained model by using formal methods; 3) to control the system behaviour to maximize the recombinant protein synthesis.

The Petri net to be designed will model the different events taking place in the protein synthesis mechanism: transcription, translation, modification, transportation, degradation and secretion. The analysis of the Petri net will consider structural and dynamical properties, and special attention will be paid to the computation of throughput bounds and bottleneck identification. As bottlenecks constrain the throughput of the whole system, any control action aiming at maximizing the protein synthesis will be performed on them.

Overall, this proposal intends to improve our understanding of the cellular mechanism regulating protein synthesis by providing mathematical modelling and analysis tools. This understanding will eventually enable us to control and optimize the synthesis of recombinant proteins, which are broadly used for vaccines, diagnostic tools and therapeutic purposes.'

Altri progetti dello stesso programma (FP7-PEOPLE)

PRODUCT-HARM CRISES (2008)

When bad things happen to good brands. On how to deal with product-harm crisis

Read More  

STATPHYSNETFORMGAME (2013)

The statistical physics of network formation games

Read More  

BSMEXPLORE (2013)

Looking for physics beyond the standard model in unexplored regions at the LHC and flavour experiments

Read More