EFIMB

Esrrb Function in Mitotic Bookmarking

 Coordinatore INSTITUT PASTEUR 

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Marie-Laure
Cognome: Rosso
Email: send email
Telefono: +33 01 44 38 95 26

 Nazionalità Coordinatore France [FR]
 Totale costo 194˙046 €
 EC contributo 194˙046 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2015
 Periodo (anno-mese-giorno) 2015-03-01   -   2017-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Marie-Laure
Cognome: Rosso
Email: send email
Telefono: +33 01 44 38 95 26

FR (PARIS CEDEX 15) coordinator 194˙046.60

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

bookmarking    pluripotency    cells    repression    mitotic    identity    mitotically    depends    gene    maintained    maintenance    es    transcription    memory   

 Obiettivo del progetto (Objective)

'The preservation of cell identity depends on the maintenance of gene expression programs through mitosis. Generally, this is mediated by epigenetic systems of repression involving Polycomb proteins and H3K9 and DNA methyltransferases. Pluripotent Embryonic Stem (ES) cells constitute an exception as abrogation of these systems does not lead to detrimental consequences, with defects appearing only during differentiation. This is particularly surprising since ES cells maintain their transcriptome and developmental potential over long periods of frequent divisions. Understanding how ES cells identity is mitotically maintained is the focus of this application. An unconventional view will be adopted in which the mitotic stability of pluripotency depends on the memory of gene activation (rather than repression). These so-called “bookmarking mechanisms” rely on transcription factors whose binding at specific genomic locations is mitotically stable, preserving and instructing gene activity from mother to daughter cells. The major hypothesis driving this proposal is therefore that memory of active transcription in ES cells is maintained by retention of one or several pluripotency transcription factors on mitotic chromatin. We have identified one such “bookmarking” factor and we propose to study its potential function on the intergenerational maintenance of ES cells identity.'

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