SHP2N

Characterization of nuclear SHP2 function in breast cancer progression and metastasis

 Coordinatore FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH 

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Mrs.
Nome: Dorothy
Cognome: Searles
Telefono: +41 616972982
Fax: +41 616973976

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 199˙317 €
 EC contributo 199˙317 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2015
 Periodo (anno-mese-giorno) 2015-03-01   -   2017-07-02

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

 Organization address address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058

contact info
Titolo: Mrs.
Nome: Dorothy
Cognome: Searles
Telefono: +41 616972982
Fax: +41 616973976

CH (BASEL) coordinator 199˙317.60

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

determine    progression    nuclear    women    breast    nucleolin    tumor    metastasis    cancer    host    function    shp   

 Obiettivo del progetto (Objective)

Breast cancer is the most frequently diagnosed cancer in women with ~1.1 million worldwide cases. Despite intense study, in a significant fraction of women, tumor progression and disease relapse is inevitable underscoring a crucial gap in our understanding of these important hallmarks. Currently, little is known about the biochemical networks controlling these processes. The host lab has shown a fundamental role for the protein tyrosine phosphatase, SHP2, in tumor progression and metastasis in two aggressive breast cancer subtypes, human epidermal growth factor 2 (HER2) positive and triple negative breast cancer. Preliminary data in breast cancer cell lines revealed nuclear localization of SHP2 and proteomic analysis identified candidate nuclear substrates including nucleolin. However, whether a nuclear function of SHP2 and how SHP2 and its binding partners (i.e nucleolin) might impact breast cancer progression and metastasis remain unknown. This proposal will take advantage of original, state-of-the art technologies including multiphoton intravital imaging developed by the host laboratory to determine the nuclear function of SHP2 in normal mammary epithelial cells and during breast cancer progression and metastasis. Finally, it will validate nucleolin (and other identified candidates) as a SHP2 nuclear substrate and determine whether it is a critical downstream effector of SHP2 in breast cancer. Elucidation of the mechanisms driving tumor progression and metastasis is paramount for the development of novel therapeutic strategies.

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