CD300SHIV

The CD300 family of receptors in HIV infection

 Coordinatore ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOCRUCES 

 Organization address address: PLAZA DE CRUCES SN
city: BARAKALDO BIZKAIA
postcode: 48903

contact info
Titolo: Mrs
Nome: Idoia
Cognome: Mínguez
Email: send email
Telefono: 34944536885
Fax: 34944530465

 Nazionalità Coordinatore Spain [ES]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-08-01   -   2018-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOCRUCES

 Organization address address: PLAZA DE CRUCES SN
city: BARAKALDO BIZKAIA
postcode: 48903

contact info
Titolo: Mrs
Nome: Idoia
Cognome: Mínguez
Email: send email
Telefono: 34944536885
Fax: 34944530465

ES (BARAKALDO BIZKAIA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    receptor    blood    inhibitory    cd    patients    cells    healthy    peripheral    samples    infected    hiv    performed   

 Obiettivo del progetto (Objective)

'This project's main objective is to study the role of the CD300 receptor family in the pathogenesis of the infection by human immunodeficiency virus (HIV) and viral escape mechanisms. We will use peripheral blood samples from patients chronically infected with HIV as well as from healthy donors. The samples will be collected in hospitals of the Basque Country, Spain. The experimental part will be performed at BioCruces Health research Institute-Cruces University Hospital. The expression of the CD300 receptors will be determined by flow cytometry techniques in cells from peripheral blood from patients and healthy subjects, and correlations studies will be performed with markers of chronic inflammation. It will be studied the CD300a inhibitory receptor in CD8 T cells in great detail, with a particular emphasis on its participation in the processes of cell exhaustion, which is defined by the loss of effector functions and proliferative capacity of memory T cells. Finally, we will determine the degree of translocation of phosphatidylserine and phosphatidylethanolamine, the two ligands of the CD300a inhibitory receptor, into the outer leaflet of the plasma membrane in HIV-infected cells, and their involvement in the functional recognition by HIV specific CD8 T cells and by NK cells. We will use recombinant viruses to infect cell lines and primary cells. We believe that the results that we will obtain can be of prognostic value and it will help to identify new targets for the treatment of this disease.'

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