Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI)


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 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 2˙000˙000 €
 EC contributo 2˙000˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-CoG
 Funding Scheme ERC-CG
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-09-01   -   2019-08-31


# participant  country  role  EC contrib. [€] 

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Dr.
Nome: Nikolaus
Cognome: Weiskopf
Email: send email
Telefono: +44 2034484381
Fax: +44 2078131420

UK (LONDON) hostInstitution 2˙000˙000.00

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Dorota
Cognome: Chmielewska
Email: send email
Telefono: +44 203 108 3064
Fax: +44 2078132849

UK (LONDON) hostInstitution 2˙000˙000.00


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cortex    disease    anatomical    vivo    previously    imaging    determined    my    microstructure    small    clinical    histology    neuroscience    columns    degeneration    focal       resolution    mri    cortical   

 Obiettivo del progetto (Objective)

'Understanding of the normal and diseased brain crucially depends on reliable knowledge of its microstructure. Important functions are mediated by small cortical units (columns) and even small changes in the microstructure can cause debilitating diseases. So far, this microstructure can only be determined using invasive methods such as, e.g., ex-vivo histology. This limits neuroscience, clinical research and diagnosis.

My research vision is to develop novel methods for high-resolution magnetic resonance imaging (MRI) at 3T-9.4T to reliably characterize and quantify the detailed microstructure of the human cortex.

This MRI-based histology will be used to investigate the cortical microstructure in health and focal cortical degeneration. Structure-function relationships in visual cortex will be elucidated in-vivo, particularly, ocular dominance columns and stripes. Specific microstructural changes in focal cortical degeneration due to Alzheimer’s disease and monocular blindness will be determined, including amyloid plaque imaging.

To resolve the subtle structures and disease related changes, which have not previously been delineated in-vivo by anatomical MRI, unprecedented isotropic imaging resolution of up to 250 µm is essential. Methods for high-resolution myelin and iron mapping will be developed from novel quantitative MRI approaches that I have previously established. Super-resolution diffusion and susceptibility imaging will be developed to capture the neuropil microstructure. Anatomical imaging will be complemented by advanced high-resolution functional MRI. The multi-modal MRI data will be integrated into a unified model of MRI contrasts, cortical anatomy and tissue microstructure.

My ambitious goal of developing in vivo MRI-based histology can only be achieved by an integrative approach combining innovations in MR physics, modelling and tailored (clinical) neuroscience experiments. If successful, the project will transform research and clinical imaging.'

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