GLIOMA

Molecular Mechanisms of Glioma Genesis and Progression

 Coordinatore FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON 

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 Nazionalità Coordinatore Spain [ES]
 Totale costo 1˙566˙000 €
 EC contributo 1˙566˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-08-01   -   2014-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE RECERCA DE L'HOSPITAL UNIVERSITARI VALL D'HEBRON

 Organization address address: Passeig Vall d'Hebron
city: BARCELONA
postcode: 8035

contact info
Titolo: Dr.
Nome: José
Cognome: Besalga Torres
Email: send email
Telefono: +34 93 274 6085
Fax: +34 93 489 4212

ES (BARCELONA) beneficiary 0.00
2    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON

 Organization address city: Barcelona
postcode: 8035

contact info
Titolo: Dr.
Nome: Joan
Cognome: Seoane
Email: send email
Telefono: +34 93 274 6026
Fax: +34 93 489 3884

ES (Barcelona) hostInstitution 0.00
3    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON

 Organization address city: Barcelona
postcode: 8035

contact info
Titolo: Mr.
Nome: Andrés
Cognome: De Kelety Alcaide
Email: send email
Telefono: 34934893021
Fax: +34 93 489 4212

ES (Barcelona) hostInstitution 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

brain    markers    models    cells    human    stem    disease    molecular    gliomas    patient    clinical    generate    biology    therapeutic    pathways    mechanisms    mouse    tumour    cell    mentioned    glioma    tumours    population   

 Obiettivo del progetto (Objective)

'Glioma is the most common and aggressive tumour of the brain and its most malignant form, glioblastoma multiforme, is nowadays virtually not curable. Very little is known about glioma genesis and progression at the molecular level and not much progress has been achieved in the treatment of this disease during the last years. The understanding of the molecular mechanisms involved in the biology of glioma is essential for the development of successful and rational therapeutic strategies. Our project aims to: 1- Study the role of the TGF-beta, Shh, Notch, and Wnt signal transduction pathways in glioma. These pathways have been implicated in glioma but still not much is known about their specific mechanisms of action. 2- Study of a cell population within the tumour mass that has stem-cell-like characteristics, the glioma stem cells, and how the four mentioned pathways regulate their biology. 3- Study the role of a transcription factor, FoxG1, that has an important oncogenic role in some gliomas and that it is regulated by the four mentioned pathways interconnecting some of them. Our approach will be based on a tight collaboration with clinical researchers of our hospital and the study of patient-derived tumours. We will analyse human biopsies, generate primary cultures of human tumour cells, isolate the stem-cell-like population of patient-derived gliomas and generate mouse models for glioma based on the orthotopical inoculation of human glioma stem cells in the mouse brain to generate tumours with the same characteristics as the original human tumour. In addition, we will also study genetically modified mouse models and established cell lines. We expect that our results will help understand the biology of glioma and cancer, and we aspire to translate our discoveries to a more clinical ambit identifying molecular markers of diagnosis and prognosis, markers of response to therapies, and unveil new therapeutic targets against this deadly disease.'

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TRANSINTEG (2011)

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AP-1-FUN (2009)

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