InTopSens

A highly integrated optical sensor for point of care label free identification of pathogenic bacteria strains and their antibiotic resistance

Coordinatore	KUNGLIGA TEKNISKA HOEGSKOLAN    more  Organization address address: KTH School of electrical Engineering 79 city: Stockholm postcode: S-100 44 contact info Titolo: Ms. Nome: Erika Cognome: Appel Email: send email Telefono: +46 8 790 7786 Fax: +46 8 100 858
Nazionalità Coordinatore	Sweden [SE]
Totale costo	3˙360˙218 €
EC contributo	2˙595˙797 €
Programma	FP7-ICT Specific Programme "Cooperation": Information and communication technologies
Code Call	FP7-ICT-2007-2
Funding Scheme	CP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-09-01   -   2012-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KUNGLIGA TEKNISKA HOEGSKOLAN  Organization address address: KTH School of electrical Engineering 79 city: Stockholm postcode: S-100 44 contact info Titolo: Ms. Nome: Erika Cognome: Appel Email: send email Telefono: +46 8 790 7786 Fax: +46 8 100 858	SE (Stockholm)	coordinator	0.00
2	AARHUS UNIVERSITET  Organization address address: Nordre Ringgade city: AARHUS C postcode: 8000 contact info Titolo: Ms. Nome: Karin Cognome: Sutherland Email: send email Telefono: +45 8942 5548 Fax: +45 8942 3690	DK (AARHUS C)	participant	0.00
3	Farfield Group Limited  Organization address address: Farfield House, Southmere Court, Electra Way, Crewe Business city: Crewe postcode: CWI 6GU contact info Titolo: Ms. Nome: Madden Cognome: Louise Email: send email Telefono: +44 870950971 Fax: +44 870950971	UK (Crewe)	participant	0.00
4	MOBIDIAG OY  Organization address address: TUKHOLMANKATU city: HELSINKI postcode: 290 contact info Titolo: Dr. Nome: Minna Cognome: Mäki Email: send email Telefono: 358408000000 Fax: 358919000000	FI (HELSINKI)	participant	0.00
5	UNIVERSITAT POLITECNICA DE VALENCIA  Organization address address: CAMINO DE VERA S/N city: VALENCIA postcode: 46022 contact info Titolo: Mr. Nome: José Antonio Cognome: Pérez García Email: send email Telefono: +34 96 3877409 Fax: +34 96 3877949	ES (VALENCIA)	participant	0.00
6	UNIVERSITEIT ANTWERPEN  Organization address address: PRINSSTRAAT city: ANTWERPEN postcode: 2000 contact info Titolo: Ms. Nome: Anne Cognome: Adams Email: send email Telefono: +32 3 2653028 Fax: +32 3 2653011	BE (ANTWERPEN)	participant	0.00
7	UNIVERSITEIT GENT  Organization address address: SINT PIETERSNIEUWSTRAAT city: GENT postcode: 9000 contact info Titolo: Ms. Nome: Nathalie Cognome: Vandepitte Email: send email Telefono: +32 9 2643029 Fax: +32 9 2643583	BE (GENT)	participant	0.00

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 Obiettivo del progetto (Objective)

InTopSens is a multidisciplinary project involving the emerging fields of photonics structures, electronics, fluidics and bio-chemistry, to contribute to the development of high value sensor technology. This objective will be addressed through the demonstration of a compact polymer and silicon-based CMOS-compatible photonics sensor system. It integrates two label-free biomolecular recognition photonic sensor technologies with sensitivities as low as 0.1ng per ml, state-of-the-art in label-free integrated optical biosensors, with novel coupling technology that will permit very high integration of hundreds of sensing areas on a 1mm2 photonics chip. This offers the further advantageous possibility of assaying several parameters simultaneously leading to further increases in the reliability and reductions in the measurement uncertainty of a diagnostic over single-parameter assays. The novel diagnostic technology of the InTopSens device has the potential to be fast and easy to use, making routine screening or monitoring of bacteria more cost-effective. The ultimate target of InTopSens is to demonstrate the feasibility of a rapid diagnostic test for sepsis at 'point of care'. From the introduction onto the chip of a large drop of blood (some 5ml) it will have after 5-10 mins a yes/no to the presence of bacteria and after less than 30mins an antibiotic resistance profile of the infecting bacteria. Some 120 sensing areas/datapoints are needed to identify this profile and as such due to the very high integration up to 250 assays can be integrated onto a 1mm2 chip for the same bacteria for higher sensitivity/selectivity or for other bacteria. A final prototype consisting of a packaged biochip will be used on clinical samples in order to detect the sepsis bacteria and determine their resistance to antibiotics.