InTopSens
A highly integrated optical sensor for point of care label free identification of pathogenic bacteria strains and their antibiotic resistance
| Coordinatore | KUNGLIGA TEKNISKA HOEGSKOLAN
Organization address
address: KTH School of electrical Engineering 79 contact info |
| Nazionalità Coordinatore | Sweden [SE] |
| Totale costo | 3˙360˙218 € |
| EC contributo | 2˙595˙797 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2007-2 |
| Funding Scheme | CP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-09-01 - 2012-02-29 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
KUNGLIGA TEKNISKA HOEGSKOLAN
Organization address
address: KTH School of electrical Engineering 79 contact info |
SE (Stockholm) | coordinator | 0.00 |
| 2 |
AARHUS UNIVERSITET
Organization address
address: Nordre Ringgade contact info |
DK (AARHUS C) | participant | 0.00 |
| 3 |
Farfield Group Limited
Organization address
address: Farfield House, Southmere Court, Electra Way, Crewe Business contact info |
UK (Crewe) | participant | 0.00 |
| 4 |
MOBIDIAG OY
Organization address
address: TUKHOLMANKATU contact info |
FI (HELSINKI) | participant | 0.00 |
| 5 |
UNIVERSITAT POLITECNICA DE VALENCIA
Organization address
address: CAMINO DE VERA S/N contact info |
ES (VALENCIA) | participant | 0.00 |
| 6 |
UNIVERSITEIT ANTWERPEN
Organization address
address: PRINSSTRAAT contact info |
BE (ANTWERPEN) | participant | 0.00 |
| 7 |
UNIVERSITEIT GENT
Organization address
address: SINT PIETERSNIEUWSTRAAT contact info |
BE (GENT) | participant | 0.00 |
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Obiettivo del progetto (Objective)
InTopSens is a multidisciplinary project involving the emerging fields of photonics structures, electronics, fluidics and bio-chemistry, to contribute to the development of high value sensor technology. This objective will be addressed through the demonstration of a compact polymer and silicon-based CMOS-compatible photonics sensor system. It integrates two label-free biomolecular recognition photonic sensor technologies with sensitivities as low as 0.1ng per ml, state-of-the-art in label-free integrated optical biosensors, with novel coupling technology that will permit very high integration of hundreds of sensing areas on a 1mm2 photonics chip. This offers the further advantageous possibility of assaying several parameters simultaneously leading to further increases in the reliability and reductions in the measurement uncertainty of a diagnostic over single-parameter assays. The novel diagnostic technology of the InTopSens device has the potential to be fast and easy to use, making routine screening or monitoring of bacteria more cost-effective. The ultimate target of InTopSens is to demonstrate the feasibility of a rapid diagnostic test for sepsis at 'point of care'. From the introduction onto the chip of a large drop of blood (some 5ml) it will have after 5-10 mins a yes/no to the presence of bacteria and after less than 30mins an antibiotic resistance profile of the infecting bacteria. Some 120 sensing areas/datapoints are needed to identify this profile and as such due to the very high integration up to 250 assays can be integrated onto a 1mm2 chip for the same bacteria for higher sensitivity/selectivity or for other bacteria. A final prototype consisting of a packaged biochip will be used on clinical samples in order to detect the sepsis bacteria and determine their resistance to antibiotics.