TOR SIGNALLING

Growth control by the TOR signalling network

 Coordinatore UNIVERSITE DE GENEVE 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 965˙449 €
 EC contributo 965˙449 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-09-01   -   2013-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Dr.
Nome: Alex
Cognome: Waehry
Email: send email
Telefono: +41 (0)22 379 75 60
Fax: +41 (0)22 379 11 80

CH (GENEVE) hostInstitution 0.00
2    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Prof.
Nome: Robbie Joseph
Cognome: Loewith
Email: send email
Telefono: 41 22 379 6116
Fax: -41 22 379 6868

CH (GENEVE) hostInstitution 0.00

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cell    readouts    signalling    complexes    tor    effectors    torc    mechanisms    regulated    regulate    screens   

 Obiettivo del progetto (Objective)

'The Target Of Rapamycin (TOR) kinases reside in two distinct multi-protein complexes: TOR Complex 1 (TORC1), and TORC2. These two complexes are conserved among eukaryotes and function in signalling pathways that regulate different aspects of cell growth. By exploiting the facile genetics of the model eukaryote Saccharomyces cerevisiae, my lab aims to flesh out details of the TOR signalling network with the ultimate goal of understanding how cell, organ and organism growth is regulated. Specifically, the molecular mechanisms that regulate their activity, and the effectors by which TORC1 and TORC2 influence their distal readouts, remain largely unknown. Using both hypothesis-driven approaches and unbiased genetic screens we want to learn how TORC1 activity is regulated by environmental cues and to identify the physiological regulators of TORC2. In addition we will use biochemical approaches to elucidate the signalling mechanisms that couple TORC1 and TORC2 to their downstream effectors/readouts. Lastly, given the conservation of the TOR complexes and their clinical importance, especially in oncology, we will employ both directed chemistry and ‘target-inferred’ high throughput chemical library screens to identify drug-like compounds that inhibit yeast and mammalian TORC1 and TORC2.'

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