BIMOC

Biomimetic Organocatalysis – Development of Novel Synthetic Catalytic Methodology and Technology

Coordinatore	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	999˙960 €
EC contributo	999˙960 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2007-StG
Funding Scheme	ERC-SG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-09-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN  Organization address address: GRUNEBURGPLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 contact info Titolo: Mr. Nome: Christoph Cognome: Denecke Email: send email Telefono: -30365 Fax: -30364	DE (FRANKFURT AM MAIN)	beneficiary	0.00
2	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN  Organization address address: Templergraben 55 city: AACHEN postcode: 52062 contact info Titolo: Dr. Nome: Magnus Cognome: Rueping Email: send email Telefono: 492418000000 Fax: 492418000000	DE (AACHEN)	hostInstitution	0.00
3	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN  Organization address address: Templergraben 55 city: AACHEN postcode: 52062 contact info Titolo: Prof. Nome: Ernst Cognome: Schmachtenberg Email: send email Telefono: 492418000000 Fax: 492418000000	DE (AACHEN)	hostInstitution	0.00

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 Obiettivo del progetto (Objective)

'Biomimetic Organocatalysis – Development of Novel Synthetic Catalytic Methodology and Technology The objective of the proposed research is the design and development of unprecedented preassembled, modular, molecular factories. Inspiration comes from nature’s non-ribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs). These large multifunctional enzymes possess catalytic modules with the capacity for recognition, activation and modification required for sequential biosynthesis of complex peptides and polyketides. Using nature as a role model we intend to design and prepare such catalyst “factories” synthetically and apply them in novel cascade reaction sequences. The single catalytic modules employed will be based on organocatalytic procedures, including enamine-, iminium-, as well as hydrogen bonding activation processes, but the potential scope is limitless. Organocatalysts have so far never been applied in a combined fashion utilizing their different activation mechanisms in multiple reaction cascades. Therefore, it is our intention to firstly demonstrate that such a production line approach is feasible and that these new catalyst systems can be applied in the synthesis of valuable enantiopure, biologically active, building blocks and natural products. Additionally, the extensive possibilities to vary organocatalyst modules in sequence will lead to science mimicking nature in its diversity.'