DEER
Developmental effects of environment on reproductive health
| Coordinatore | TURUN YLIOPISTO
Organization address
address: YLIOPISTONMAKI contact info |
| Nazionalità Coordinatore | Finland [FI] |
| Totale costo | 4˙615˙781 € |
| EC contributo | 3˙499˙028 € |
| Programma | FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change) |
| Code Call | FP7-ENV-2007-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-05-01 - 2012-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
TURUN YLIOPISTO
Organization address
address: YLIOPISTONMAKI contact info |
FI (TURUN YLIOPISTO) | coordinator | 0.00 |
| 2 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 0.00 |
| 3 |
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE
Organization address
address: Site de la Chantrerie, Route de Gachet contact info |
FR (NANTES) | participant | 0.00 |
| 4 |
INSTITUTE OF EXPERIMENTAL MORPHOLOGY AND ANTHROPOLOGY WITH MUSEUM- BAS
Organization address
address: "AKAD G BONCHEV STREET, BLOCK 25" contact info |
BG (SOFIA) | participant | 0.00 |
| 5 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 0.00 |
| 6 |
RIGSHOSPITALET
Organization address
address: Blegdamsvej 9 contact info |
DK (KOEPENHAGEN) | participant | 0.00 |
| 7 |
UNIVERSIDAD DE CORDOBA
Organization address
address: AVENIDA DE MEDINA AZAHARA 5 contact info |
ES (CORDOBA) | participant | 0.00 |
| 8 |
UNIVERSITE DE RENNES I
Organization address
address: RUE DU THABOR 2 contact info |
FR (RENNES CEDEX) | participant | 0.00 |
| 9 |
UNIVERSITY OF ROCHESTER
Organization address
address: "ELMWOOD AVENUE, BOX EHSC 601" contact info |
US (ROCHESTER NY) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'The multidisciplinary research teams in this consortium have played lead roles in establishing that fetal and childhood periods are vulnerable to environmental disruption leading to common reproductive disorders. This proposal will investigate: (1) connections between normal/abnormal perinatal reproductive development and maturation of reproductive function at puberty and in adulthood; (2) systemic gene-environment interactions underlying reproductive disorders taking account of genetic susceptibility, multiple exposures (e.g. mixtures of environmental chemicals) and their timing (perinatal, peripubertal, adult); (3) connection between perinatal reproductive development and later obesity/metabolic disorders. To achieve this we will utilize large cohorts generated in previous EU projects and collect new data from these on reproductive maturation and adult function. Existing genomic and proteomics data, exposure data for >100 potentially toxic environmental chemicals, lifestyle, dietary and medical history information will be analysed using integrative systems biology approaches to pinpoint critical (interacting) factors influencing development. Established animal models will be used to test putative mechanisms by analysing the roles of neuroendocrine regulation, intrauterine growth, time windows of reproductive development, metabolic balance and xenobiotic metabolism. Toxicogenomics, proteomics and metabolomics results from these studies will identify pathways for study in the human cohorts. The overall aim is to create new cause-effect frameworks and knowledge networks to refine research in this critical area and to identify novel biomarkers of exposure and disease. The proposed studies will facilitate prediction and prevention of reproductive disorders and provide large new datasets and exposure-outcome information to improve environmental risk assessment and risk management.'
Introduzione (Teaser)
An EU-funded project aimed to elucidate the possible link between male reproductive health problems and developmental (foetal and neonatal) exposure to common environmental chemicals.