TRANSYS

A systems approach to defining membrane protein networks and applications

 Coordinatore THE UNIVERSITY OF WARWICK 

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Ms.
Nome: Kate
Cognome: Hughes
Email: send email
Telefono: -48580
Fax: -99179

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 2˙000˙000 €
 EC contributo 2˙000˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2007-1-1-ITN
 Funding Scheme MC-ITN
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-09-01   -   2012-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Ms.
Nome: Kate
Cognome: Hughes
Email: send email
Telefono: -48580
Fax: -99179

UK (COVENTRY) coordinator 0.00
2    ACADEMISCH ZIEKENHUIS GRONINGEN

 Organization address address: Hanzeplein 1
city: GRONINGEN
postcode: 9713 GZ

contact info
Titolo: Dr.
Nome: Anthoni Jan
Cognome: Kee
Email: send email
Telefono: -3632663
Fax: -3632902

NL (GRONINGEN) participant 0.00
3    INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

 Organization address address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
Titolo: Mr.
Nome: Angelo
Cognome: Trussardi
Email: send email
Telefono: +33 1 34 65 20 40
Fax: +33 1 34 65 21 46

FR (PARIS CEDEX 07) participant 0.00
4    NOVOZYMES A/S

 Organization address address: Krogshoejvej 36
city: BAGSVAERD
postcode: 2880

contact info
Titolo: Dr.
Nome: Michael
Cognome: Rasmus
Email: send email
Telefono: -44463911
Fax: -44467258

DK (BAGSVAERD) participant 0.00
5    STOCKHOLMS UNIVERSITET

 Organization address address: Universitetsvaegen 10
city: STOCKHOLM
postcode: 10691

contact info
Titolo: Prof.
Nome: Arne
Cognome: Elofsson
Email: send email
Telefono: -164634
Fax: +46-8-5537 8214

SE (STOCKHOLM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    biology    structure    academic    complexes    network    multidisciplinary    biotechnological    protein    training    membrane    proteins   

 Obiettivo del progetto (Objective)

'Membrane proteins are macromolecules of huge academic and biotechnological importance. They account for ~30% of genes in prokaryotic and eukaryotic genomes, and perform a spectrum of essential cellular functions. Despite their importance, these proteins are poorly understood with respect to membrane insertion, folding and complex formation. Even less is known of the interactions between membrane protein complexes, or with other compartments in the cell. This application aims to establish a multidisciplinary initial training network for early-stage researchers in which leading European groups in membrane protein chemistry, bacterial systems biology and biotechnological applications join forces to achieve top-level training in an ambitious academic and industrial setting. Training and research will be fully integrated in a systems approach for the hierarchical analysis of membrane proteins. Key objectives are to understand how individual membrane proteins insert and adopt a unique structure (Research Topic 1), how they assemble into multimeric complexes (Research Topic 2), and how they communicate ('network') with each other and the rest of the cell (Research Topic 3). Novel quantitative approaches combined with mathematical modelling will be used to accurately predict membrane protein behaviour at a systems level (Research Topic 4). Throughout the program, special emphasis will be focused on biotechnologically relevant protein secretion systems. Major scientific deliverables will be knowledge models of complex assembly and inter-complex interaction hubs. The proposed training program will be individually-tailored to provide a coherent grounding in multidisciplinary approaches, both theoretical and experimental. It will deliver network-wide systems biology training, and a comprehensive suite of local complementary skills training. In this way, we will provide our trainees with formidable starting points for careers in European science and industry.'

Introduzione (Teaser)

The precise structure and function of membrane proteins could be important in several sectors including biotechnology and agriculture. However, this requires multi-disciplinary expertise.

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